PRMT2 Antibody (PACO14902)
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주문- SKU:
- PACO14902
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | PRMT2 Antibody (PACO14902) |
Antibody SKU: | PACO14902 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human PRMT2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO14902(PRMT2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO14902(PRMT2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Protein arginine N-methyltransferase 2 is an enzyme that in humans is encoded by the PRMT2 gene. Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation. |
Synonyms: | protein arginine methyltransferase 2 |
UniProt Protein Function: | PRMT2: Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner). May be involved in growth regulation. Belongs to the protein arginine N-methyltransferase family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Methyltransferase; Methyltransferase, protein arginine; Nuclear receptor co-regulator; EC 2.1.1.125; Nucleolus Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: nucleoplasm; Rb-E2F complex; cytoplasm; nucleolus; nucleus; cytosol Molecular Function:histone methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity; protein-arginine N-methyltransferase activity; peroxisome proliferator activated receptor binding; protein homodimerization activity; retinoic acid receptor binding; transcription coactivator activity; histone-arginine N-methyltransferase activity; protein binding; signal transducer activity; androgen receptor binding; estrogen receptor binding; thyroid hormone receptor binding; progesterone receptor binding Biological Process: histone methylation; developmental cell growth; protein amino acid methylation; inhibition of NF-kappaB transcription factor; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; signal transduction; negative regulation of transcription, DNA-dependent |
UniProt Code: | P55345 |
NCBI GenInfo Identifier: | 2499805 |
NCBI Gene ID: | 3275 |
NCBI Accession: | P55345.1 |
UniProt Secondary Accession: | P55345,P78350, Q498Y5, Q5U7D4, Q6FHF0, Q99781, Q9BW15 Q9UMC2, B7U630, B7U631, B7U632, |
UniProt Related Accession: | P55345 |
Molecular Weight: | 433 |
NCBI Full Name: | Protein arginine N-methyltransferase 2 |
NCBI Synonym Full Names: | protein arginine methyltransferase 2 |
NCBI Official Symbol: | PRMT2 |
NCBI Official Synonym Symbols: | HRMT1L1 |
NCBI Protein Information: | protein arginine N-methyltransferase 2; PRMT2 beta; PRMT2 alpha; PRMT2 gamma; HMT1 hnRNP methyltransferase-like 1; histone-arginine N-methyltransferase PRMT2; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1 |
UniProt Protein Name: | Protein arginine N-methyltransferase 2 |
UniProt Synonym Protein Names: | Histone-arginine N-methyltransferase PRMT2 (EC:2.1.1.125) |
UniProt Gene Name: | PRMT2 |
UniProt Entry Name: | ANM2_HUMAN |