PRKACG Antibody (PACO49894)
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주문- SKU:
- PACO49894
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | PRKACG Antibody (PACO49894) |
Antibody SKU: | PACO49894 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:200-1:3000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human cAMP-dependent protein kinase catalytic subunit γ protein (1-43AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human liver cancer using PACO49894 at dilution of 1:100. | |
Western Blot. Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate. All lanes: PRKACG antibody at 3.2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 41 kDa. Observed band size: 41 kDa. |
Background: | Phosphorylates a large number of substrates in the cytoplasm and the nucleus. |
Synonyms: | cAMP-dependent protein kinase catalytic subunit γ (PKA C-gamma) (EC 2.7.11.11), PRKACG |
UniProt Protein Function: | PKACG: Phosphorylates a large number of substrates in the cytoplasm and the nucleus. A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Testis specific. But important tissues such as brain and ovary have not been analyzed for the content of transcript. Activated by cAMP. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. |
UniProt Protein Details: | Protein type:Protein kinase, AGC; EC 2.7.11.11; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; AGC group; PKA family Chromosomal Location of Human Ortholog: 9q13 Cellular Component: cytosol Molecular Function:cAMP-dependent protein kinase activity; ATP binding Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; male gonad development; glucose metabolic process; pathogenesis; signal transduction; protein amino acid phosphorylation; gluconeogenesis; phospholipase C activation; triacylglycerol catabolic process; carbohydrate metabolic process; energy reserve metabolic process; innate immune response; renal water homeostasis; spermatogenesis; blood coagulation; regulation of insulin secretion; transmembrane transport Disease: Mental Retardation, Autosomal Dominant 31 |
NCBI Summary: | Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. [provided by RefSeq, Jul 2008] |
UniProt Code: | P22612 |
NCBI GenInfo Identifier: | 207029159 |
NCBI Gene ID: | 5568 |
NCBI Accession: | NP_002723.2 |
UniProt Secondary Accession: | P22612,O60850, Q5VZ02, Q86YI1, |
UniProt Related Accession: | P22612 |
Molecular Weight: | 65.0 kDa |
NCBI Full Name: | Homo sapiens protein kinase, cAMP-dependent, catalytic, gamma (PRKACG), mRNA |
NCBI Synonym Full Names: | protein kinase, cAMP-dependent, catalytic, gamma |
NCBI Official Symbol: | PRKACG |
NCBI Official Synonym Symbols: | KAPG; PKACg; BDPLT19 |
NCBI Protein Information: | cAMP-dependent protein kinase catalytic subunit gamma |
UniProt Protein Name: | cAMP-dependent protein kinase catalytic subunit gamma |
Protein Family: | Protein lysine acetyltransferase |
UniProt Gene Name: | PRKACG |
UniProt Entry Name: | KAPCG_HUMAN |