UniProt Protein Function: | PPP2R1B: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Belongs to the phosphatase 2A regulatory subunit A family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Protein phosphatase, regulatory subunit Chromosomal Location of Human Ortholog: 11q23.2 Cellular Component: lipid raft Molecular Function:protein binding Disease: Lung Cancer |
NCBI Summary: | This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010] |
UniProt Code: | P30154 |
NCBI GenInfo Identifier: | 116241236 |
NCBI Gene ID: | 5519 |
NCBI Accession: | P30154.3 |
UniProt Secondary Accession: | P30154,O75620, Q8NHV8, A8MY67, B0YJ69, B4DGQ6, B4DK91 B4DWW5, F8W8G1, |
UniProt Related Accession: | P30154 |
Molecular Weight: | 52,214 Da |
NCBI Full Name: | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform |
NCBI Synonym Full Names: | protein phosphatase 2 scaffold subunit Abeta |
NCBI Official Symbol: | PPP2R1B |
NCBI Official Synonym Symbols: | PR65B; PP2A-Abeta |
NCBI Protein Information: | serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform |
UniProt Protein Name: | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform |
UniProt Synonym Protein Names: | PP2A subunit A isoform PR65-beta; PP2A subunit A isoform R1-beta |
UniProt Gene Name: | PPP2R1B |
UniProt Entry Name: | 2AAB_HUMAN |