PPFIA1 Antibody (PACO45612)
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주문- SKU:
- PACO45612
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PPFIA1 Antibody (PACO45612) |
Antibody SKU: | PACO45612 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Liprin-alpha-1 protein (660-800AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human testis tissue using PACO45612 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human endometrial cancer using PACO45612 at dilution of 1:100. |
Background: | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. |
Synonyms: | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1), PPFIA1, LIP1 |
UniProt Protein Function: | liprin alpha 1: a ubiqutous member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Two alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cell adhesion Chromosomal Location of Human Ortholog: 11q13.3 Cellular Component: focal adhesion; cytoplasm; presynaptic active zone; cytosol Molecular Function:signal transducer activity; protein binding Biological Process: synaptic transmission; negative regulation of stress fiber formation; glutamate secretion; cell-matrix adhesion; neurotransmitter secretion; signal transduction |
NCBI Summary: | The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q13136 |
NCBI GenInfo Identifier: | 42558969 |
NCBI Gene ID: | 8500 |
NCBI Accession: | Q13136.1 |
UniProt Related Accession: | Q13136 |
Molecular Weight: | |
NCBI Full Name: | Liprin-alpha-1 |
NCBI Synonym Full Names: | PTPRF interacting protein alpha 1 |
NCBI Official Symbol: | PPFIA1 |
NCBI Official Synonym Symbols: | LIP1; LIP.1; LIPRIN |
NCBI Protein Information: | liprin-alpha-1 |
UniProt Protein Name: | Liprin-alpha-1 |
UniProt Synonym Protein Names: | LAR-interacting protein 1; LIP-1; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1; PTPRF-interacting protein alpha-1 |
Protein Family: | Lipoyl synthase |
UniProt Gene Name: | PPFIA1 |
UniProt Entry Name: | LIPA1_HUMAN |