POLG2 Antibody (PACO22307)
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주문- SKU:
- PACO22307
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | POLG2 Antibody (PACO22307) |
Antibody SKU: | PACO22307 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:50-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthesized peptide derived from internal of human POLG2. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma tissue using POLG2 antibody. |
Background: | Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA. |
Synonyms: | DNA polymerase subunit gamma-2; mitochondrial; EC 2.7.7.7; Mitochondrial DNA polymerase accessory subunit; PolG-beta |
UniProt Protein Function: | POLG2: Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA. Defects in POLG2 are the cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 4 (PEOA4). Progressive external ophthalmoplegia is characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged- red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism. |
UniProt Protein Details: | Protein type:DNA replication; EC 2.7.7.7; Transferase; Mitochondrial; DNA repair, damage Chromosomal Location of Human Ortholog: 17q Cellular Component: mitochondrial matrix Molecular Function:glycine-tRNA ligase activity; protein binding Biological Process: DNA-dependent DNA replication; glycyl-tRNA aminoacylation; mitochondrion organization and biogenesis Disease: Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant, 4 |
NCBI Summary: | This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.[provided by RefSeq, Sep 2009] |
UniProt Code: | Q9UHN1 |
NCBI GenInfo Identifier: | 17367139 |
NCBI Gene ID: | 11232 |
NCBI Accession: | Q9UHN1.1 |
UniProt Secondary Accession: | Q9UHN1,O00419, Q0IJ81, Q96GW2, Q9UK35, Q9UK94, |
UniProt Related Accession: | Q9UHN1 |
Molecular Weight: | 54,911 Da |
NCBI Full Name: | DNA polymerase subunit gamma-2, mitochondrial |
NCBI Synonym Full Names: | DNA polymerase gamma 2, accessory subunit |
NCBI Official Symbol: | POLG2 |
NCBI Official Synonym Symbols: | HP55; POLB; PEOA4; POLGB; MTPOLB; POLG-BETA |
NCBI Protein Information: | DNA polymerase subunit gamma-2, mitochondrial |
UniProt Protein Name: | DNA polymerase subunit gamma-2, mitochondrial |
UniProt Synonym Protein Names: | DNA polymerase gamma accessory 55 kDa subunit; p55; Mitochondrial DNA polymerase accessory subunit; MtPolB; PolG-beta |
Protein Family: | DNA polymerase |
UniProt Gene Name: | POLG2 |
UniProt Entry Name: | DPOG2_HUMAN |
Antibodies |
Anti-POLG2 Antibody (CAB14504) |
Anti-POLG2 Antibody (CAB6695) |
POLG2 Antibody (PACO03389) |
POLG2 Antibody (PACO11347) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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