PLK3 Antibody (PACO00812)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO00812
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | PLK3 Antibody |
Antibody SKU: | PACO00812 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from the Internal region of human Fnk. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | PLK3; CNK; FNK; PRK; Serine/threonine-protein kinase PLK3; Cytokine-inducible serine/threonine-protein kinase; FGF-inducible kinase; Polo-like kinase 3; PLK-3; Proliferation-related kinase |
UniProt Protein Function: | PLK3: a kinase of the PLK family. Phosphorylated and activated following DNA damage or mitotic spindle disruption. Interacts with Chk2 and the interaction is enhanced upon DNA damage. Apparent substrates include Chk2 and p53. Plays an important role in regulating microtubule dynamics and centrosomal function. Deregulated expression of Plk3 results in cell cycle arrest and apoptosis. |
UniProt Protein Details: | Protein type:Kinase, protein; Nucleolus; EC 2.7.11.21; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; PLK family Chromosomal Location of Human Ortholog: 1p34.1 Cellular Component: centrosome; cytoplasm; Golgi stack; nucleolus; nucleoplasm; nucleus Molecular Function:p53 binding; protein binding; protein serine/threonine kinase activity Biological Process: apoptosis; cytoplasmic microtubule organization and biogenesis; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; endomitotic cell cycle; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; mitotic cell cycle checkpoint; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; protein kinase B signaling cascade; regulation of cell division; regulation of cytokinesis; response to DNA damage stimulus; response to osmotic stress; response to radiation; response to reactive oxygen species |
NCBI Summary: | The protein encoded by this gene is a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases are important regulators of cell cycle progression. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus. Expression of a kinase-defective mutant results in abnormal cell morphology caused by changes in microtubule dynamics and mitotic arrest followed by apoptosis. [provided by RefSeq, Sep 2015] |
UniProt Code: | Q9H4B4 |
NCBI GenInfo Identifier: | 51338822 |
NCBI Gene ID: | 1263 |
NCBI Accession: | Q9H4B4.2 |
UniProt Secondary Accession: | Q9H4B4,Q15767, Q5JR99, Q96CV1, |
UniProt Related Accession: | Q9H4B4 |
Molecular Weight: | 71,629 Da |
NCBI Full Name: | Serine/threonine-protein kinase PLK3 |
NCBI Synonym Full Names: | polo like kinase 3 |
NCBI Official Symbol: | PLK3 |
NCBI Official Synonym Symbols: | CNK; FNK; PRK; PLK-3 |
NCBI Protein Information: | serine/threonine-protein kinase PLK3 |
UniProt Protein Name: | Serine/threonine-protein kinase PLK3 |
UniProt Synonym Protein Names: | Cytokine-inducible serine/threonine-protein kinase; FGF-inducible kinase; Polo-like kinase 3; PLK-3; Proliferation-related kinase |
Protein Family: | Serine/threonine-protein kinase |
UniProt Gene Name: | PLK3 |
UniProt Entry Name: | PLK3_HUMAN |