PLCL1 Antibody (PACO60044)
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주문- SKU:
- PACO60044
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PLCL1 Antibody (PACO60044) |
Antibody SKU: | PACO60044 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Inactive phospholipase C-like protein 1 protein (1-108AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | IHC image of PACO60044 diluted at 1:300 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
![]() | Immunofluorescence staining of A549 cells with PACO60044 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
![]() | IHC image of PACO60044 diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
Background: | Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C. |
Synonyms: | Inactive phospholipase C-like protein 1 (PLC-L1) (Phospholipase C-deleted in lung carcinoma) (Phospholipase C-related but catalytically inactive protein) (PRIP), PLCL1 |
UniProt Protein Function: | PLCL1: a protein closely related to phospholipase C-d1 (PLC-d1) but catalytically inactive. First identified as a novel inositol 1,4,5-trisphosphate binding protein. Has a number of binding partners including protein phosphatase (PP1 and 2A), GABA(A) receptor associated protein, and the beta subunits of GABA(A) receptors, in addition to inositol 1,4,5-trisphosphate. Plays an important role in controlling the dynamics of GABA(A) receptor phosphorylation through PP1 binding and, therefore, the efficacy of synaptic inhibition mediated by these receptors. |
UniProt Protein Details: | Protein type:Phospholipase Chromosomal Location of Human Ortholog: 2q33 Molecular Function:phospholipase C activity |
UniProt Code: | Q15111 |
NCBI GenInfo Identifier: | 226694170 |
NCBI Gene ID: | 5334 |
NCBI Accession: | Q15111.3 |
UniProt Secondary Accession: | Q15111,Q3MJ90, Q53SD3, Q7Z3S3, |
UniProt Related Accession: | Q15111 |
Molecular Weight: | 113,012 Da |
NCBI Full Name: | Inactive phospholipase C-like protein 1 |
NCBI Synonym Full Names: | phospholipase C like 1 |
NCBI Official Symbol: | PLCL1 |
NCBI Official Synonym Symbols: | PLCE; PLCL; PRIP; PLDL1; PPP1R127 |
NCBI Protein Information: | inactive phospholipase C-like protein 1 |
UniProt Protein Name: | Inactive phospholipase C-like protein 1 |
UniProt Synonym Protein Names: | Phospholipase C-deleted in lung carcinoma; Phospholipase C-related but catalytically inactive protein; PRIP |
Protein Family: | Inactive phospholipase C-like protein |
UniProt Gene Name: | PLCL1 |
UniProt Entry Name: | PLCL1_HUMAN |
Antibodies |
Anti-PLCL1 Antibody (CAB15302) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |