Plasma Kallikrein/KLKB1 Recombinant Protein (RPES2062)

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SKU:
RPES2062
Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
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Description

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Plasma Kallikrein/KLKB1 Recombinant Protein

KLKB1 is a 638 amino acids protein that belongs to the peptidase S1 family and plasma kallikrein subfamily. It contains a peptidase S1 domain and four apple domains. The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. It participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation.Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.

Product Name:Plasma Kallikrein/KLKB1 Recombinant Protein (RPES2062)
Product Code:RPES2062
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Plasma kallikrein,Fletcher factor,Kininogenin,Plasma prekallikrein,KLKB1,KLK3
Accession:P03952
Sequence:Gly20-Ala638
Fusion tag:C-6His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Plasma kallikrein is produced by our Mammalian expression system and the target gene encoding Gly20-Ala638 is expressed with a 6His tag at the C-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:70.2 kDa
AP Mol Mass:75-87 kDa
Formulation:Supplied as a 0.2 µm filtered solution of 20mM TrisHCl,150mM NaCl,10% Glycerol,pH8.0.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Stability and Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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