PKP2 Antibody (PACO06766)
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주문- SKU:
- PACO06766
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | PKP2 Antibody (PACO06766) |
Antibody SKU: | PACO06766 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:20000, WB:1:500-1:2000 |
Species Reactivity: | Human, Rat |
Immunogen: | Synthesized peptide derived from the C-terminal region of human Plakophilin 2. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot analysis of Jurakt 293 cells using Plakophilin 2 Polyclonal Antibody. |
![]() | Western Blot analysis of HepG2 cells using Plakophilin 2 Polyclonal Antibody. |
Synonyms: | PKP2; Plakophilin-2 |
UniProt Protein Function: | plakophilin 2: May play a role in junctional plaques. Defects in PKP2 are the cause of familial arrhythmogenic right ventricular dysplasia type 9 (ARVD9); also known as arrhythmogenic right ventricular cardiomyopathy 9 (ARVC9). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Belongs to the beta-catenin family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral Chromosomal Location of Human Ortholog: 12p11 Cellular Component: nucleoplasm; desmosome; adherens junction; plasma membrane; integral to membrane; intermediate filament; intercellular junction; nucleus; cell junction Molecular Function:protein binding; sodium channel regulator activity; protein kinase C binding; intermediate filament binding; protein complex scaffold Biological Process: negative regulation of cell proliferation; cell-cell adhesion; gap junction assembly; heart development; lipid homeostasis; ventricular cardiac muscle morphogenesis; intermediate filament bundle assembly; maintenance of organ identity; negative regulation of cell migration Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 9 |
NCBI Summary: | This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q99959 |
NCBI GenInfo Identifier: | 296452867 |
NCBI Gene ID: | 5318 |
NCBI Accession: | Q99959.2 |
UniProt Secondary Accession: | Q99959,Q4VC01, Q99960, A0AV37, B8QFA1, B8QGS6, B8QGS7 D3DUW9, |
UniProt Related Accession: | Q99959 |
Molecular Weight: | 92,756 Da |
NCBI Full Name: | Plakophilin-2 |
NCBI Synonym Full Names: | plakophilin 2 |
NCBI Official Symbol: | PKP2 |
NCBI Official Synonym Symbols: | ARVD9 |
NCBI Protein Information: | plakophilin-2 |
UniProt Protein Name: | Plakophilin-2 |
Protein Family: | Plakophilin |
UniProt Gene Name: | PKP2 |
UniProt Entry Name: | PKP2_HUMAN |
Antibodies |
Anti-PKP2 Antibody (CAB5507) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |