PITRM1 Antibody (PACO44359)
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주문- SKU:
- PACO44359
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PITRM1 Antibody (PACO44359) |
Antibody SKU: | PACO44359 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Presequence protease, mitochondrial protein (758-1037AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: PITRM1 antibody at 2µg/ml. Lane 1: A549 whole cell lysate. Lane 2: Mouse kidney tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 118, 107 kDa. Observed band size: 118 kDa.. |
![]() | Immunohistochemistry of paraffin-embedded human brain tissue using PACO44359 at dilution of 1:100. |
Background: | ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid β A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. |
Synonyms: | Presequence protease, mitochondrial (hPreP) (EC 3.4.24.-) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1), PITRM1, KIAA1104 MP1 |
UniProt Protein Function: | PITRM1: ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Belongs to the peptidase M16 family. PreP subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Mitochondrial; Protease; EC 3.4.24.-; Activator Chromosomal Location of Human Ortholog: 10p15.2 Cellular Component: mitochondrial matrix; mitochondrion Molecular Function:enzyme activator activity; metalloendopeptidase activity; zinc ion binding Biological Process: protein processing; proteolysis |
UniProt Code: | Q5JRX3 |
NCBI GenInfo Identifier: | 485956568 |
NCBI Gene ID: | 10531 |
NCBI Accession: | Q5JRX3.3 |
UniProt Secondary Accession: | Q5JRX3,O95204, Q2M2G6, Q4VBR1, Q5JRW7, Q7L5Z7, Q9BSI6 Q9BVJ5, B3KMJ6, B4E0J8, C9JSL2, E7ES23, |
UniProt Related Accession: | Q5JRX3 |
Molecular Weight: | 106,065 Da |
NCBI Full Name: | Presequence protease, mitochondrial |
NCBI Synonym Full Names: | pitrilysin metallopeptidase 1 |
NCBI Official Symbol: | PITRM1 |
NCBI Official Synonym Symbols: | MP1; PreP |
NCBI Protein Information: | presequence protease, mitochondrial |
UniProt Protein Name: | Presequence protease, mitochondrial |
UniProt Synonym Protein Names: | Pitrilysin metalloproteinase 1; Metalloprotease 1; hMP1 |
UniProt Gene Name: | PITRM1 |
UniProt Entry Name: | PREP_HUMAN |