PIK3C3 Antibody (PACO52698)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO52698
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | PIK3C3 Antibody (PACO52698) |
Antibody SKU: | PACO52698 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Phosphatidylinositol 3-kinase catalytic subunit type 3 protein (700-850AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: Hela whole cell lysate. All lanes: PIK3C3 antibody at 3.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 102 kDa. Observed band size: 102 kDa. |
![]() | Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO52698 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human heart tissue using PACO52698 at dilution of 1:100. |
Background: | Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity). |
Synonyms: | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34), PIK3C3, VPS34 |
UniProt Protein Function: | PIK3C3: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes. Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4. Forms a complex with BECN1, PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. In this complex, presence of UVRAG and ATG14 are mutually exclusive. Part of a complex composed of PIK3R4 and PIK3CB. Interacts with RAB7A in the presence of PIK3R4. Ubiquitously expressed, with a highest expression in skeletal muscle. Belongs to the PI3/PI4-kinase family. |
UniProt Protein Details: | Protein type:EC 2.7.1.137; Autophagy; Carbohydrate Metabolism - inositol phosphate; Motility/polarity/chemotaxis; Kinase, lipid Chromosomal Location of Human Ortholog: 18q12.3 Cellular Component: membrane; late endosome; phagocytic vesicle; midbody; axoneme; phosphoinositide 3-kinase complex; cytosol Molecular Function:protein binding; 1-phosphatidylinositol-3-kinase activity; ATP binding; protein kinase activity Biological Process: phosphoinositide-mediated signaling; endosome organization and biogenesis; cytokinesis; protein amino acid phosphorylation; regulation of protein secretion; response to leucine; phosphoinositide phosphorylation; early endosome to late endosome transport; phospholipid metabolic process; phosphatidylinositol biosynthetic process; toll-like receptor signaling pathway; insulin receptor signaling pathway; innate immune response; protein processing; toll-like receptor 9 signaling pathway; autophagic vacuole formation |
UniProt Code: | Q8NEB9 |
NCBI GenInfo Identifier: | 74730233 |
NCBI Gene ID: | 5289 |
NCBI Accession: | Q8NEB9.1 |
UniProt Secondary Accession: | Q8NEB9,Q15134, |
UniProt Related Accession: | Q8NEB9 |
Molecular Weight: | 101,549 Da |
NCBI Full Name: | Phosphatidylinositol 3-kinase catalytic subunit type 3 |
NCBI Synonym Full Names: | phosphatidylinositol 3-kinase, catalytic subunit type 3 |
NCBI Official Symbol: | PIK3C3 |
NCBI Official Synonym Symbols: | VPS34; Vps34; hVps34 |
NCBI Protein Information: | phosphatidylinositol 3-kinase catalytic subunit type 3 |
UniProt Protein Name: | Phosphatidylinositol 3-kinase catalytic subunit type 3 |
UniProt Synonym Protein Names: | Phosphatidylinositol 3-kinase p100 subunit; Phosphoinositide-3-kinase class 3; hVps34 |
UniProt Gene Name: | PIK3C3 |
UniProt Entry Name: | PK3C3_HUMAN |
Antibodies |
Anti-PIK3C3 Antibody (CAB0952) |
Anti-PIK3C3 Antibody (CAB12483) |
Anti-PIK3C3 Antibody (CAB4021) |
Anti-PI 3 Kinase Class 3 Antibody (CAB12295) |
PIK3C3 Antibody (PACO07258) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |