Phospho-TNNI3 (Thr142) Antibody (PACO23948)
- SKU:
- PACO23948
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | Phospho-TNNI3 (Thr142) Antibody (PACO23948) |
Antibody SKU: | PACO23948 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:1000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Peptide sequence around phosphorylation site of Threonine 142(R-P-T(p)-L-R) derived from Human TNNI3. |
Form: | Liquid |
Storage Buffer: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from Mouse heart tissue using TNNI3 (Phospho-Thr142) Antibody.The lane on the left is treated with the antigen-specific peptide. |
Background: | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
Synonyms: | CMH7, RCM1, cTnI, CMD2A, TNNC1 |
UniProt Protein Function: | TNNI3: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1. Belongs to the troponin I family. |
UniProt Protein Details: | Protein type:Actin-binding; Motility/polarity/chemotaxis; Motor Chromosomal Location of Human Ortholog: 19q13.4 Cellular Component: cytosol; sarcomere; troponin complex Molecular Function:actin binding; calcium channel inhibitor activity; calcium-dependent protein binding; metal ion binding; protein binding; protein domain specific binding; protein kinase binding; troponin C binding; troponin T binding Biological Process: cardiac muscle contraction; cellular calcium ion homeostasis; heart contraction; heart development; muscle filament sliding; negative regulation of ATPase activity; regulation of smooth muscle contraction; regulation of systemic arterial blood pressure by ischemic conditions; skeletal muscle contraction; vasculogenesis; ventricular cardiac muscle morphogenesis Disease: Cardiomyopathy, Dilated, 1ff; Cardiomyopathy, Dilated, 2a; Cardiomyopathy, Familial Hypertrophic, 7; Cardiomyopathy, Familial Restrictive, 1 |
NCBI Summary: | Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008] |
UniProt Code: | P19429 |
NCBI GenInfo Identifier: | 136213 |
NCBI Gene ID: | 7137 |
NCBI Accession: | P19429.3 |
UniProt Secondary Accession: | P19429,P48787, P23693, |
UniProt Related Accession: | P19429 |
Molecular Weight: | 24,008 Da |
NCBI Full Name: | Troponin I, cardiac muscle |
NCBI Synonym Full Names: | troponin I3, cardiac type |
NCBI Official Symbol: | TNNI3 |
NCBI Official Synonym Symbols: | CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF |
NCBI Protein Information: | troponin I, cardiac muscle |
UniProt Protein Name: | Troponin I, cardiac muscle |
UniProt Synonym Protein Names: | Cardiac troponin I |
Protein Family: | Troponin |
UniProt Gene Name: | TNNI3 |
UniProt Entry Name: | TNNI3_HUMAN |
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