Phospho-STXBP1 (S313) Antibody (PACO05150)
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주문- SKU:
- PACO05150
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Reactivity:
- Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | Phospho-STXBP1 (S313) Antibody (PACO05150) |
Antibody SKU: | PACO05150 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:5000, WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse, Rat, Monkey |
Immunogen: | Synthesized peptide derived from human Unc18-1 around the phosphorylation site of S313. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | STXBP1; UNC18A; Syntaxin-binding protein 1; MUNC18-1; N-Sec1; Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A; Unc-18A; p67 |
UniProt Protein Function: | STXBP1: may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. Two splice-variant isoforms have been described. |
UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 9q34.1 Cellular Component: cytoplasm; cytosol; mitochondrion; myelin sheath; nucleoplasm; plasma membrane; protein complex; terminal button Molecular Function:identical protein binding; protein binding; protein domain specific binding; protein kinase binding; protein N-terminus binding; SNARE binding; syntaxin binding; syntaxin-1 binding Biological Process: axon target recognition; energy reserve metabolic process; glutamate secretion; negative regulation of neuron apoptosis; negative regulation of synaptic transmission, GABAergic; neuromuscular synaptic transmission; neurotransmitter secretion; platelet degranulation; positive regulation of calcium ion-dependent exocytosis; protein stabilization; protein transport; regulation of insulin secretion; regulation of synaptic vesicle fusion to presynaptic membrane; synaptic transmission; synaptic vesicle maturation; vesicle docking during exocytosis Disease: Epileptic Encephalopathy, Early Infantile, 4 |
NCBI Summary: | This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010] |
UniProt Code: | P61764 |
NCBI GenInfo Identifier: | 50403646 |
NCBI Gene ID: | 6812 |
NCBI Accession: | P61764.1 |
UniProt Secondary Accession: | P61764,Q28208, Q62759, Q64320, Q96TG8, B1AM97, |
UniProt Related Accession: | P61764 |
Molecular Weight: | 68,736 Da |
NCBI Full Name: | Syntaxin-binding protein 1 |
NCBI Synonym Full Names: | syntaxin binding protein 1 |
NCBI Official Symbol: | STXBP1 |
NCBI Official Synonym Symbols: | P67; NSEC1; UNC18; RBSEC1; MUNC18-1 |
NCBI Protein Information: | syntaxin-binding protein 1 |
UniProt Protein Name: | Syntaxin-binding protein 1 |
UniProt Synonym Protein Names: | MUNC18-1; N-Sec1; Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A; Unc-18A; p67 |
Protein Family: | Syntaxin-binding protein |
UniProt Gene Name: | STXBP1 |
UniProt Entry Name: | STXB1_HUMAN |