Phospho-CRKL (Y207) Antibody (PACO00324)
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주문- SKU:
- PACO00324
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Reactivity:
- Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | Phospho-CRKL (Y207) Antibody |
Antibody SKU: | PACO00324 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
Species Reactivity: | Human, Mouse, Rat, Monkey |
Immunogen: | synthesized peptide derived from human Crk-L around the phosphorylation site of Y207. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | CRKL; Crk-like protein |
UniProt Protein Function: | CRKL: an oncogenic adaptor protein with an SH2-SH3-SH3 domain structure. Plays a specific role in integrin-induced migration as a downstream mediator of Src. Activates the RAS and Jnk signaling pathways. Transforms fibroblasts in a RAS-dependent fashion. A substrate of BCR-ABL and plays a role in fibroblast transformation by BCR-ABL. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 22q11.21 Cellular Component: cytosol; endosome Molecular Function:protein binding; SH3/SH2 adaptor activity; signal transducer activity Biological Process: activation of MAPKK activity; JNK cascade; positive regulation of cell proliferation; Ras protein signal transduction |
NCBI Summary: | This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009] |
UniProt Code: | P46109 |
NCBI GenInfo Identifier: | 1169094 |
NCBI Gene ID: | 1399 |
NCBI Accession: | P46109.1 |
UniProt Secondary Accession: | P46109,A8KA44, D3DX35, |
UniProt Related Accession: | P46109 |
Molecular Weight: | 33,777 Da |
NCBI Full Name: | Crk-like protein |
NCBI Synonym Full Names: | CRK like proto-oncogene, adaptor protein |
NCBI Official Symbol: | CRKL |
NCBI Protein Information: | crk-like protein |
UniProt Protein Name: | Crk-like protein |
Protein Family: | Crk-like protein |
UniProt Gene Name: | CRKL |
UniProt Entry Name: | CRKL_HUMAN |