| UniProt Protein Function: | PFKFB1: Synthesis and degradation of fructose 2,6-bisphosphate. Homodimer. Liver. Phosphorylation results in inhibition of the kinase activity. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Kinase, other; EC 3.1.3.46; Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; Phosphatase (non-protein) Chromosomal Location of Human Ortholog: Xp11.21 Cellular Component: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex; cytosol Molecular Function:6-phosphofructo-2-kinase activity; fructose-2,6-bisphosphate 2-phosphatase activity; identical protein binding; protein binding Biological Process: fructose 2,6-bisphosphate metabolic process; gluconeogenesis; glycolysis |
| NCBI Summary: | This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012] |
| UniProt Code: | P16118 |
| NCBI GenInfo Identifier: | 2507178 |
| NCBI Gene ID: | 5207 |
| NCBI Accession: | P16118.3 |
| UniProt Secondary Accession: | P16118,Q5JXS5, Q99951, B2RA88, B4DUN5, |
| UniProt Related Accession: | P16118 |
| Molecular Weight: | 47,426 Da |
| NCBI Full Name: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 |
| NCBI Synonym Full Names: | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 |
| NCBI Official Symbol: | PFKFB1 |
| NCBI Official Synonym Symbols: | F6PK; HL2K; PFRX |
| NCBI Protein Information: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 |
| UniProt Protein Name: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 |
| UniProt Synonym Protein Names: | 6PF-2-K/Fru-2,6-P2ase liver isozymeIncluding the following 2 domains:6-phosphofructo-2-kinase (EC:2.7.1.105)Fructose-2,6-bisphosphatase (EC:3.1.3.46) |
| Protein Family: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase |
| UniProt Gene Name: | PFKFB1 |
| UniProt Entry Name: | F261_HUMAN |
