PDE4C Antibody (PACO22221)
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주문- SKU:
- PACO22221
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PDE4C Antibody (PACO22221) |
Antibody SKU: | PACO22221 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from internal of human PDE4C. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot analysis of extracts from A549 cells, RAW264.7 cells and HuvEc cells, using PDE4C antibody. |
Background: | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. |
Synonyms: | cAMP-specific 3; 5-cyclic phosphodiesterase 4C; CN4C; DPDE1; PDE21 |
UniProt Protein Function: | PDE4C: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. 7 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Phosphodiesterase; EC 3.1.4.53; Nucleotide Metabolism - purine Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: cytosol; extracellular space Molecular Function:3',5'-cyclic-AMP phosphodiesterase activity |
NCBI Summary: | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011] |
UniProt Code: | Q08493 |
NCBI GenInfo Identifier: | 20141263 |
NCBI Gene ID: | 5143 |
NCBI Accession: | Q08493.2 |
UniProt Secondary Accession: | Q08493,Q9UN44, Q9UN45, Q9UN46, Q9UPJ6, B3KTC4, |
UniProt Related Accession: | Q08493 |
Molecular Weight: | – Da |
NCBI Full Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
NCBI Synonym Full Names: | phosphodiesterase 4C |
NCBI Official Symbol: | PDE4C |
NCBI Official Synonym Symbols: | DPDE1 |
NCBI Protein Information: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
UniProt Protein Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
UniProt Synonym Protein Names: | DPDE1; PDE21 |
Protein Family: | cAMP-specific 3',5'-cyclic phosphodiesterase |
UniProt Gene Name: | PDE4C |
UniProt Entry Name: | PDE4C_HUMAN |