UniProt Protein Function: | PDE1A: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP. Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. 9 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.1.4.17; Phosphodiesterase; Nucleotide Metabolism - purine Chromosomal Location of Human Ortholog: 2q32.1 Cellular Component: cell soma; nucleus; cytosol Molecular Function:calmodulin binding; 3',5'-cyclic-AMP phosphodiesterase activity; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; metal ion binding; cGMP binding Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; regulation of smooth muscle cell proliferation; nerve growth factor receptor signaling pathway; phospholipase C activation; cAMP catabolic process; innate immune response; cGMP catabolic process; signal transduction; blood coagulation |
NCBI Summary: | Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009] |
UniProt Code: | P54750 |
NCBI GenInfo Identifier: | 1705942 |
NCBI Gene ID: | 5136 |
NCBI Accession: | P54750.2 |
UniProt Secondary Accession: | P54750,Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2 Q9C0L3, Q9C0L4, Q9UFX3, D3DPG5, |
UniProt Related Accession: | P54750 |
Molecular Weight: | 535 |
NCBI Full Name: | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A |
NCBI Synonym Full Names: | phosphodiesterase 1A, calmodulin-dependent |
NCBI Official Symbol: | PDE1A |
NCBI Official Synonym Symbols: | HCAM1; HCAM-1; HSPDE1A; CAM-PDE-1A |
NCBI Protein Information: | calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; cam-PDE 1A; 61 kDa Cam-PDE; calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase |
UniProt Protein Name: | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A |
UniProt Synonym Protein Names: | 61 kDa Cam-PDE; hCam-1 |
Protein Family: | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase |
UniProt Gene Name: | PDE1A |
UniProt Entry Name: | PDE1A_HUMAN |