PDCD2 Antibody (PACO18819)
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주문- SKU:
- PACO18819
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PDCD2 Antibody (PACO18819) |
Antibody SKU: | PACO18819 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:200-1:1000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human PDCD2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO18819(PDCD2 Antibody) at dilution 1/10, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: PACO18819(PDCD2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18819(PDCD2 Antibody) at dilution 1/10, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. |
Synonyms: | Programmed cell death 2 |
UniProt Protein Function: | PDCD2: May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 6q27 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; enzyme binding; DNA binding; metal ion binding Biological Process: caspase activation; apoptosis; positive regulation of apoptosis |
NCBI Summary: | This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. [provided by RefSeq, Dec 2010] |
UniProt Code: | Q16342 |
NCBI GenInfo Identifier: | 14249983 |
NCBI Gene ID: | 5134 |
NCBI Accession: | AAH08378.1 |
UniProt Secondary Accession: | Q16342,Q58HM9, Q58HN0, Q9UH12, E9PCU7, F5GYS7, |
UniProt Related Accession: | Q16342 |
Molecular Weight: | 21,299 Da |
NCBI Full Name: | Programmed cell death 2 |
NCBI Synonym Full Names: | programmed cell death 2 |
NCBI Official Symbol: | PDCD2 |
NCBI Official Synonym Symbols: | RP8; ZMYND7 |
NCBI Protein Information: | programmed cell death protein 2; zinc finger protein Rp-8; zinc finger MYND domain-containing protein 7 |
UniProt Protein Name: | Programmed cell death protein 2 |
UniProt Synonym Protein Names: | Zinc finger MYND domain-containing protein 7; Zinc finger protein Rp-8 |
Protein Family: | Programmed cell death protein |
UniProt Gene Name: | PDCD2 |
UniProt Entry Name: | PDCD2_HUMAN |