PARP3 Antibody (PACO16841)
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주문- SKU:
- PACO16841
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PARP3 Antibody (PACO16841) |
Antibody SKU: | PACO16841 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human PARP3 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16841(PARP3 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16841(PARP3 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. |
Synonyms: | poly (ADP-ribose) polymerase family, member 3 |
UniProt Protein Function: | PARP3: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA repair, damage; EC 2.4.2.30; Transferase Chromosomal Location of Human Ortholog: 3p21.2 Cellular Component: centriole; nucleus Molecular Function:catalytic activity; NAD+ ADP-ribosyltransferase activity Biological Process: protein amino acid ADP-ribosylation; double-strand break repair; positive regulation of DNA ligation; DNA repair; telomere maintenance |
NCBI Summary: | The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9Y6F1 |
NCBI GenInfo Identifier: | 224471880 |
NCBI Gene ID: | 10039 |
NCBI Accession: | Q9Y6F1.3 |
UniProt Secondary Accession: | Q9Y6F1,Q8NER9, Q96CG2, Q9UG81, |
UniProt Related Accession: | Q9Y6F1 |
Molecular Weight: | 533 |
NCBI Full Name: | Poly |
NCBI Synonym Full Names: | poly (ADP-ribose) polymerase family, member 3 |
NCBI Official Symbol: | PARP3 |
NCBI Official Synonym Symbols: | IRT1; ARTD3; ADPRT3; ADPRTL2; ADPRTL3; PADPRT-3 |
NCBI Protein Information: | poly [ADP-ribose] polymerase 3; poly [ADP-ribose] polymerase 3; ADPRT-3; poly[ADP-ribose] synthase 3; NAD+ ADP-ribosyltransferase 3; poly(ADP-ribose) synthetase-3; poly[ADP-ribose] synthetase 3; NAD(+) ADP-ribosyltransferase 3; ADP-ribosyltransferase diphtheria toxin-like 3; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 2; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3 |
UniProt Protein Name: | Poly [ADP-ribose] polymerase 3 |
UniProt Synonym Protein Names: | ADP-ribosyltransferase diphtheria toxin-like 3; ARTD3; IRT1; NAD(+) ADP-ribosyltransferase 3; ADPRT-3; Poly[ADP-ribose] synthase 3; pADPRT-3 |
Protein Family: | Poly [ADP-ribose] polymerase |
UniProt Gene Name: | PARP3 |
UniProt Entry Name: | PARP3_HUMAN |