P2RY6 Antibody (PACO18322)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO18322
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | P2RY6 Antibody (PACO18322) |
Antibody SKU: | PACO18322 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human P2RY6 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18322(P2RY6 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human brain malignant glioma tissue, Primary antibody: PACO18322(P2RY6 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18322(P2RY6 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. Four transcript variants encoding the same isoform have been identified for this gene |
Synonyms: | pyrimidinergic receptor P2Y, G-protein coupled, 6 |
UniProt Protein Function: | P2Y6: Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR Chromosomal Location of Human Ortholog: 11q13.5 Cellular Component: integral to plasma membrane; basolateral plasma membrane; apical plasma membrane; plasma membrane Molecular Function:G-protein coupled receptor activity; UDP-activated nucleotide receptor activity; purinergic nucleotide receptor activity, G-protein coupled Biological Process: transepithelial chloride transport; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of smooth muscle cell migration |
NCBI Summary: | The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013] |
UniProt Code: | Q15077 |
NCBI GenInfo Identifier: | 2495018 |
NCBI Gene ID: | 5031 |
NCBI Accession: | Q15077.1 |
UniProt Related Accession: | Q15077 |
Molecular Weight: | 36kDa |
NCBI Full Name: | P2Y purinoceptor 6 |
NCBI Synonym Full Names: | pyrimidinergic receptor P2Y6 |
NCBI Official Symbol: | P2RY6 |
NCBI Official Synonym Symbols: | P2Y6 |
NCBI Protein Information: | P2Y purinoceptor 6 |
UniProt Protein Name: | P2Y purinoceptor 6 |
UniProt Gene Name: | P2RY6 |
UniProt Entry Name: | P2RY6_HUMAN |