OVOL2 Antibody (PACO47206)
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주문- SKU:
- PACO47206
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | OVOL2 Antibody (PACO47206) |
Antibody SKU: | PACO47206 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Transcription factor Ovo-like 2 protein (19-114AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO47206 at dilution of 1:100. |
Background: | Zinc-finger transcription repressor factor. Plays a critical role to maintain the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition mainly through the up-regulation of ZEB1 expression. Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. |
Synonyms: | Transcription factor Ovo-like 2 (hOvo2) (Zinc finger protein 339), OVOL2, ZNF339 |
UniProt Protein Function: | OVOL2: DNA-binding protein that binds to the 5'-G[GCT]GGGGG-3' core sequence. Probably acts as a transcription regulator. Belongs to the krueppel C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA-binding; C2H2-type zinc finger protein Chromosomal Location of Human Ortholog: 20p11.23 Cellular Component: nucleus Disease: Corneal Dystrophy, Posterior Polymorphous, 1 |
NCBI Summary: | This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy. [provided by RefSeq, Apr 2016] |
UniProt Code: | Q9BRP0 |
NCBI GenInfo Identifier: | 743405586 |
NCBI Gene ID: | 58495 |
NCBI Accession: | NP_001290390.1 |
UniProt Secondary Accession: | Q9BRP0,Q5T8B4, Q9BX22, Q9HA54, Q9Y4M0, |
UniProt Related Accession: | Q9BRP0 |
Molecular Weight: | 16,565 Da |
NCBI Full Name: | transcription factor Ovo-like 2 isoform 2 |
NCBI Synonym Full Names: | ovo like zinc finger 2 |
NCBI Official Symbol: | OVOL2 |
NCBI Official Synonym Symbols: | PPCD1; ZNF339; EUROIMAGE566589 |
NCBI Protein Information: | transcription factor Ovo-like 2 |
UniProt Protein Name: | Transcription factor Ovo-like 2 |
UniProt Synonym Protein Names: | Zinc finger protein 339 |
Protein Family: | Transcription factor |
UniProt Gene Name: | OVOL2 |
UniProt Entry Name: | OVOL2_HUMAN |
Antibodies |
Anti-OVOL2 Antibody (CAB17973) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |