OSMR Antibody (PACO52722)
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주문- SKU:
- PACO52722
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | OSMR Antibody (PACO52722) |
Antibody SKU: | PACO52722 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Oncostatin-M-specific receptor subunit β protein (120-193AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO52722 at dilution of 1:100. | |
Immunofluorescent analysis of MCF-7 cells using PACO52722 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. |
Synonyms: | Oncostatin-M-specific receptor subunit β (Interleukin-31 receptor subunit beta) (IL-31 receptor subunit beta) (IL-31R subunit beta) (IL-31R-beta) (IL-31RB), OSMR, OSMRB |
UniProt Protein Function: | OSMR: Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. Defects in OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1); also known as familial lichen amyloidosis or familial cutaneous lichen amyloidosis. PLCA1 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. Belongs to the type I cytokine receptor family. Type 2 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Receptor, cytokine; Membrane protein, integral Chromosomal Location of Human Ortholog: 5p13.1 Cellular Component: oncostatin-M receptor complex Molecular Function:oncostatin-M receptor activity; growth factor binding Biological Process: positive regulation of acute inflammatory response; response to cytokine stimulus; positive regulation of cell proliferation Disease: Amyloidosis, Primary Localized Cutaneous, 1 |
NCBI Summary: | This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009] |
UniProt Code: | Q99650 |
NCBI GenInfo Identifier: | 74724833 |
NCBI Gene ID: | 9180 |
NCBI Accession: | Q99650.1 |
UniProt Secondary Accession: | Q99650,Q6P4E8, Q96QJ6, |
UniProt Related Accession: | Q99650 |
Molecular Weight: | Calculated MW: 39kDa/110kDaObserved MW: 111kDa |
NCBI Full Name: | Oncostatin-M-specific receptor subunit beta |
NCBI Synonym Full Names: | oncostatin M receptor |
NCBI Official Symbol: | OSMR |
NCBI Official Synonym Symbols: | OSMRB; PLCA1 |
NCBI Protein Information: | oncostatin-M-specific receptor subunit beta; IL-31RB; IL-31R-beta; IL-31R subunit beta; IL-31 receptor subunit beta; interleukin-31 receptor subunit beta; oncostatin-M specific receptor beta subunit |
UniProt Protein Name: | Oncostatin-M-specific receptor subunit beta |
UniProt Synonym Protein Names: | Interleukin-31 receptor subunit beta; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB |
Protein Family: | Oncostatin-M-specific receptor |
UniProt Gene Name: | OSMR |
UniProt Entry Name: | OSMR_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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