OS9 Antibody (PACO50470)
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주문- SKU:
- PACO50470
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | OS9 Antibody (PACO50470) |
Antibody SKU: | PACO50470 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Protein OS-9 protein (232-413AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: HepG2 whole cell lysate, HEK293 whole cell lysate. All lanes: OS9 antibody at 3.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 76, 70, 68, 74, 66, 64, 61 kDa. Observed band size: 70 kDa.. |
![]() | Immunohistochemistry of paraffin-embedded human lung cancer using PACO50470 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human testis tissue using PACO50470 at dilution of 1:100. |
Background: | Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4. |
Synonyms: | Protein OS-9 (Amplified in osteosarcoma 9), OS9 |
UniProt Protein Function: | OS9: Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4. Belongs to the OS-9 family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Endoplasmic reticulum Chromosomal Location of Human Ortholog: 12q13 Cellular Component: endoplasmic reticulum lumen; endoplasmic reticulum membrane Molecular Function:glycoprotein binding; protein binding Biological Process: ER-associated protein catabolic process; protein retention in ER; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process |
NCBI Summary: | This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q13438 |
NCBI GenInfo Identifier: | 3024310 |
NCBI Gene ID: | 10956 |
NCBI Accession: | Q13438.1 |
UniProt Secondary Accession: | Q13438,A6NDD1, A6NFR7, A6NLB2, A8K5Q9, B4DE28, B4DPX1 B4E1I6, E7ENT8, E7EW91, F8VUH2, G3XA88, |
UniProt Related Accession: | Q13438 |
Molecular Weight: | 60,847 Da |
NCBI Full Name: | Protein OS-9 |
NCBI Synonym Full Names: | OS9, endoplasmic reticulum lectin |
NCBI Official Symbol: | OS9 |
NCBI Official Synonym Symbols: | OS-9; ERLEC2 |
NCBI Protein Information: | protein OS-9 |
UniProt Protein Name: | Protein OS-9 |
UniProt Synonym Protein Names: | Amplified in osteosarcoma 9 |
Protein Family: | Protein |
UniProt Gene Name: | OS9 |
UniProt Entry Name: | OS9_HUMAN |