NRDC Antibody (PACO56908)
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주문- SKU:
- PACO56908
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NRDC Antibody (PACO56908) |
Antibody SKU: | PACO56908 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Nardilysin protein (32-113AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: K562 whole cell lysate, PC-3 whole cell lysate. All lanes: NRDC antibody at 3.73µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 132, 140 kDa. Observed band size: 132 kDa. |
![]() | Immunofluorescence staining of Hela cells with PACO56908 at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. |
Synonyms: | Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) (Nardilysin convertase), NRDC, NRD1 |
UniProt Protein Function: | NRD1: Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Belongs to the peptidase M16 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Protease; EC 3.4.24.61 Chromosomal Location of Human Ortholog: 1p32.2-p32.1 Cellular Component: cell surface; cytosol Molecular Function:epidermal growth factor binding; metalloendopeptidase activity; protein binding; zinc ion binding Biological Process: cell migration; cell proliferation; neuromuscular junction development; positive regulation of membrane protein ectodomain proteolysis; protein processing; regulation of endopeptidase activity |
NCBI Summary: | This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] |
UniProt Code: | O43847 |
NCBI GenInfo Identifier: | 29840826 |
NCBI Gene ID: | 4898 |
NCBI Accession: | O43847.2 |
UniProt Secondary Accession: | O43847,O15241, O15242, Q5VUL0, Q96HB2, Q9NU57, A6NI41 |
UniProt Related Accession: | O43847 |
Molecular Weight: | 139,284 Da |
NCBI Full Name: | Nardilysin |
NCBI Synonym Full Names: | nardilysin convertase |
NCBI Official Symbol: | NRDC |
NCBI Official Synonym Symbols: | NRD1; hNRD1; hNRD2 |
NCBI Protein Information: | nardilysin |
UniProt Protein Name: | Nardilysin |
UniProt Synonym Protein Names: | N-arginine dibasic convertase; NRD convertase; NRD-C; Nardilysin convertase |
Protein Family: | Negative regulator of differentiation |
UniProt Gene Name: | NRDC |
UniProt Entry Name: | NRDC_HUMAN |
Antibodies |
Anti-Nardilysin Antibody (CAB9119) |
Anti-NRD1 Antibody (CAB19857)[KO Validated] |
NRD1 Antibody (PACO10930) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |