NR2F2 Antibody (PACO23211)
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주문- SKU:
- PACO23211
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | NR2F2 Antibody (PACO23211) |
Antibody SKU: | PACO23211 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IF:1:100-1:500 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthesized peptide derived from N-terminal of human COT2. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot analysis of extracts from HUVEC cells, using COT2 antibody. |
![]() | Immunofluorescence analysis of HUVEC cells, using COT2 antibody. |
Background: | Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. |
Synonyms: | COUP transcription factor 2; COUP-TF2; COUP-TF II; Nuclear receptor subfamily 2 group F member 2; Apolipoprotein AI regulatory protein 1 |
UniProt Protein Function: | NR2F2: Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. Interacts with SQSTM1. Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2. Ubiquitous. Belongs to the nuclear hormone receptor family. NR2 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor Chromosomal Location of Human Ortholog: 15q26.2 Cellular Component: nucleus Molecular Function:ligand-dependent nuclear receptor activity; protein binding; protein homodimerization activity; retinoic acid binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity Biological Process: lipid metabolic process; negative regulation of cyclin-dependent protein kinase activity; negative regulation of endothelial cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; signal transduction Disease: Congenital Heart Defects, Multiple Types, 4 |
NCBI Summary: | This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] |
UniProt Code: | P24468 |
NCBI GenInfo Identifier: | 114203 |
NCBI Gene ID: | 7026 |
NCBI Accession: | P24468.1 |
UniProt Secondary Accession: | P24468,Q03754, Q3KQR7, B4DQJ2, B6ZGU1, |
UniProt Related Accession: | P24468 |
Molecular Weight: | 46kDa |
NCBI Full Name: | COUP transcription factor 2 |
NCBI Synonym Full Names: | nuclear receptor subfamily 2 group F member 2 |
NCBI Official Symbol: | NR2F2 |
NCBI Official Synonym Symbols: | ARP1; CHTD4; NF-E3; NR2F1; SVP40; COUPTFB; TFCOUP2; COUPTFII |
NCBI Protein Information: | COUP transcription factor 2 |
UniProt Protein Name: | COUP transcription factor 2 |
UniProt Synonym Protein Names: | Apolipoprotein A-I regulatory protein 1; ARP-1; COUP transcription factor II; COUP-TF II; Nuclear receptor subfamily 2 group F member 2 |
Protein Family: | COUP transcription factor |
UniProt Gene Name: | NR2F2 |