NR2C1 Antibody (PACO10921)
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주문- SKU:
- PACO10921
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NR2C1 Antibody (PACO10921) |
Antibody SKU: | PACO10921 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human NR2C1 |
Form: | Liquid |
Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | nuclear receptor subfamily 2, group C, member 1;NR2C1;TR2 ; |
UniProt Protein Function: | NR2C1: Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid- regulated preadipocyte proliferation. Belongs to the nuclear hormone receptor family. NR2 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA-binding; Nuclear receptor Chromosomal Location of Human Ortholog: 12q22 Cellular Component: nucleoplasm; PML body Molecular Function:protein binding; protein homodimerization activity; DNA binding; zinc ion binding; sequence-specific DNA binding; histone deacetylase binding; steroid hormone receptor activity; receptor activity; transcription factor activity Biological Process: transcription initiation from RNA polymerase II promoter; steroid hormone mediated signaling; positive regulation of retinoic acid receptor signaling pathway; gene expression; negative regulation of transcription from RNA polymerase II promoter |
NCBI Summary: | This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | P13056 |
NCBI GenInfo Identifier: | 226693548 |
NCBI Gene ID: | 7181 |
NCBI Accession: | P13056.2 |
UniProt Secondary Accession: | P13056,Q15625, Q15626, A8K5K4, |
UniProt Related Accession: | P13056 |
Molecular Weight: | 603 |
NCBI Full Name: | Nuclear receptor subfamily 2 group C member 1 |
NCBI Synonym Full Names: | nuclear receptor subfamily 2, group C, member 1 |
NCBI Official Symbol: | NR2C1 |
NCBI Official Synonym Symbols: | TR2 |
NCBI Protein Information: | nuclear receptor subfamily 2 group C member 1; orphan nuclear receptor TR2; TR2 nuclear hormone receptor; nuclear receptor subfamily 2, group C isoform |
UniProt Protein Name: | Nuclear receptor subfamily 2 group C member 1 |
UniProt Synonym Protein Names: | Orphan nuclear receptor TR2; Testicular receptor 2 |
Protein Family: | Nuclear receptor subfamily |
UniProt Gene Name: | NR2C1 |
UniProt Entry Name: | NR2C1_HUMAN |