NLRP7 Antibody (PACO19305)
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주문- SKU:
- PACO19305
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NLRP7 Antibody (PACO19305) |
Antibody SKU: | PACO19305 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human NLRP7 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19305(NLRP7 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19305(NLRP7 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-β secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Synonyms: | NLR family, pyrin domain containing 7 |
UniProt Protein Function: | NLRP7: Inhibits CASP1/caspase-1-dependent IL1B secretion. Defects in NLRP7 are the cause of hydatidiform mole recurrent type 1 (HYDM1). A disorder characterized by excessive trophoblast development and the presence of a growing mass of tissue inside the uterus at the beginning of a pregnancy. It leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi. Belongs to the NLRP family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Apoptosis Chromosomal Location of Human Ortholog: 19q13.42 Disease: Hydatidiform Mole, Recurrent, 1 |
NCBI Summary: | This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8WX94 |
NCBI GenInfo Identifier: | 24212128 |
NCBI Gene ID: | 199713 |
NCBI Accession: | Q8WX94.1 |
UniProt Secondary Accession: | Q8WX94,Q32MH8, Q7RTR1, E9PE16, |
UniProt Related Accession: | Q8WX94 |
Molecular Weight: | 112kDa |
NCBI Full Name: | NACHT, LRR and PYD domains-containing protein 7 |
NCBI Synonym Full Names: | NLR family pyrin domain containing 7 |
NCBI Official Symbol: | NLRP7 |
NCBI Official Synonym Symbols: | HYDM; PAN7; NALP7; NOD12; PYPAF3; CLR19.4 |
NCBI Protein Information: | NACHT, LRR and PYD domains-containing protein 7 |
UniProt Protein Name: | NACHT, LRR and PYD domains-containing protein 7 |
UniProt Synonym Protein Names: | Nucleotide-binding oligomerization domain protein 12; PYRIN-containing APAF1-like protein 3 |
Protein Family: | NACHT, LRR and PYD domains-containing protein |
UniProt Gene Name: | NLRP7 |
Antibodies |
Anti-NLRP7 Antibody (CAB11627) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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