NFKBIE Antibody (PACO45549)
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주문- SKU:
- PACO45549
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NFKBIE Antibody (PACO45549) |
Antibody SKU: | PACO45549 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human NF-kappa-B inhibitor epsilon protein (140-280AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: NFKBIE antibody at 4.17µg/ml. Lane 1: Mouse liver tissue. Lane 2: Hela whole cell lysate. Lane 3: Jurkat whole cell lysate. Lane 4: A375 whole cell lysate. Lane 5: 293T whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 53 kDa. Observed band size: 53 kDa.. |
![]() | Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO45549 at dilution of 1:100. |
Background: | Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. |
Synonyms: | NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon), NFKBIE, IKBE |
UniProt Protein Function: | IkB-epsilon: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit. Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages. Belongs to the NF-kappa-B inhibitor family. |
UniProt Protein Details: | Protein type:DNA-binding; Inhibitor Chromosomal Location of Human Ortholog: 6p21.1 Cellular Component: cytoplasm; cytosol Molecular Function:protein binding Biological Process: cytoplasmic sequestering of transcription factor |
NCBI Summary: | The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011] |
UniProt Code: | O00221 |
NCBI GenInfo Identifier: | 206729919 |
NCBI Gene ID: | 4794 |
NCBI Accession: | O00221.3 |
UniProt Secondary Accession: | O00221,Q5T9V9, |
UniProt Related Accession: | O00221 |
Molecular Weight: | 52,864 Da |
NCBI Full Name: | NF-kappa-B inhibitor epsilon |
NCBI Synonym Full Names: | NFKB inhibitor epsilon |
NCBI Official Symbol: | NFKBIE |
NCBI Official Synonym Symbols: | IKBE |
NCBI Protein Information: | NF-kappa-B inhibitor epsilon |
UniProt Protein Name: | NF-kappa-B inhibitor epsilon |
UniProt Synonym Protein Names: | I-kappa-B-epsilon; IkB-E; IkB-epsilon; IkappaBepsilon |
Protein Family: | NF-kappa-B inhibitor |
UniProt Gene Name: | NFKBIE |
UniProt Entry Name: | IKBE_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |