NEUROG3 Antibody (PACO23514)
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주문- SKU:
- PACO23514
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | NEUROG3 Antibody (PACO23514) |
Antibody SKU: | PACO23514 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Full length fusion protein |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Gel: 12%SDS-PAGE Lysates (from left to right): Mouse liver tissue Amount of lysate: 50ug per lane Primary antibody: 1/250 dilution Secondary antibody dilution: 1/8000 Exposure time: 40 seconds. |
![]() | Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/30. |
Background: | Neurogenin-3 is a protein that in humans is encoded by the NEUROG3 gene. Neurogenin-3 is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine. It belongs to a family of basic helix-loop-helix (bHLH) transcription factors involved in the determination of neural precursor cells in the neuroectoderm. The pancreas and brain the major splicing isoform does not code for a protein. Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. |
Synonyms: | ngn3; Atoh5; NGN-3; Math4B; bHLHa7 |
UniProt Protein Function: | neurogenin 3: Acts as a transcriptional regulator. Together with NKX2- 2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types. Defects in NEUROG3 are the cause of diarrhea type 4 (DIAR4). DIAR4 is a characterized by severe, life- threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells. |
UniProt Protein Details: | Protein type:Cell development/differentiation; Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 10q21.3 Cellular Component: cytoplasm; nucleus Molecular Function:protein dimerization activity; chromatin DNA binding; double-stranded DNA binding; transcription coactivator activity Biological Process: nervous system development; central nervous system development; transcription, DNA-dependent; regulation of dendrite morphogenesis; negative regulation of transcription from RNA polymerase II promoter; endocrine pancreas development; peripheral nervous system development; epithelial cell differentiation; spinal cord development; forebrain development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; positive regulation of neuron differentiation; hindbrain development Disease: Diarrhea 4, Malabsorptive, Congenital |
NCBI Summary: | The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010] |
UniProt Code: | Q9Y4Z2 |
NCBI GenInfo Identifier: | 229462908 |
NCBI Gene ID: | 50674 |
NCBI Accession: | Q9Y4Z2.2 |
UniProt Secondary Accession: | Q9Y4Z2,Q5VVI0, Q6DJX6, Q9BY24, |
UniProt Related Accession: | Q9Y4Z2 |
Molecular Weight: | 214 |
NCBI Full Name: | Neurogenin-3 |
NCBI Synonym Full Names: | neurogenin 3 |
NCBI Official Symbol: | NEUROG3 |
NCBI Official Synonym Symbols: | ngn3; Atoh5; NGN-3; Math4B; bHLHa7 |
NCBI Protein Information: | neurogenin-3; protein atonal homolog 5; class A basic helix-loop-helix protein 7 |
UniProt Protein Name: | Neurogenin-3 |
UniProt Synonym Protein Names: | Class A basic helix-loop-helix protein 7; bHLHa7; Protein atonal homolog 5 |
UniProt Gene Name: | NEUROG3 |
UniProt Entry Name: | NGN3_HUMAN |