NEK8 Antibody (PACO44889)
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주문- SKU:
- PACO44889
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NEK8 Antibody (PACO44889) |
Antibody SKU: | PACO44889 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Serine/threonine-protein kinase Nek8 protein (1-300AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human colon cancer using PACO44889 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human gastric cancer using PACO44889 at dilution of 1:100. |
Background: | Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway. |
Synonyms: | Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (Nima-related protein kinase 12a), NEK8, JCK NEK12A |
UniProt Protein Function: | NEK8: a protein kinase related to the NIMA (never in mitosis, gene A) serine/threonine kinase of Aspergillus nidulans. May play a role in mitotic regulation.Required for renal tubular integrity. |
UniProt Protein Details: | Protein type:EC 2.7.11.1; Protein kinase, tyrosine (non-receptor); Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; NEK family Chromosomal Location of Human Ortholog: 17q11.1 Cellular Component: cytoskeleton; cytoplasm Molecular Function:protein serine/threonine kinase activity; protein binding; metal ion binding; ATP binding Biological Process: organ morphogenesis; mitotic cell cycle; protein amino acid phosphorylation; microtubule-based process Disease: Renal-hepatic-pancreatic Dysplasia 2; Nephronophthisis 9 |
NCBI Summary: | This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q86SG6 |
NCBI GenInfo Identifier: | 34098463 |
NCBI Gene ID: | 284086 |
NCBI Accession: | Q86SG6.1 |
UniProt Secondary Accession: | Q86SG6,Q14CL7, Q2M1S6, Q8NDH1, A6NIC5, |
UniProt Related Accession: | Q86SG6 |
Molecular Weight: | Calculated MW: 74kDaObserved MW: 80kDa |
NCBI Full Name: | Serine/threonine-protein kinase Nek8 |
NCBI Synonym Full Names: | NIMA-related kinase 8 |
NCBI Official Symbol: | NEK8 |
NCBI Official Synonym Symbols: | JCK; NPHP9; RHPD2; NEK12A |
NCBI Protein Information: | serine/threonine-protein kinase Nek8; nephrocystin 9; NIMA-family kinase NEK8; NIMA-related kinase 12a; nimA-related protein kinase 8; nima-related protein kinase 12a; never in mitosis A-related kinase 8; serine/thrionine-protein kinase NEK8; NIMA (never in mitosis gene a)- related kinase 8 |
UniProt Protein Name: | Serine/threonine-protein kinase Nek8 |
UniProt Synonym Protein Names: | Never in mitosis A-related kinase 8; NimA-related protein kinase 8; Nima-related protein kinase 12a |
Protein Family: | Serine/threonine-protein kinase |
UniProt Gene Name: | NEK8 |
UniProt Entry Name: | NEK8_HUMAN |
Antibodies |
Anti-NEK8 Antibody (CAB0984) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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