UniProt Protein Function: | NEK2: a protein kinase of the NEK family. Accumulates throughout S phase and shows maximal levels in late G2. This expression pattern is highly reminiscent of that of A and B cyclins. Phosphorylation of Hec1 by Nek2 is essential for faithful chromosome segregation |
UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Nucleolus; Protein kinase, Other; EC 2.7.11.1; Other group; NEK family Chromosomal Location of Human Ortholog: 1q32.3 Cellular Component: kinetochore; spindle pole; microtubule; centrosome; intercellular bridge; protein complex; condensed nuclear chromosome; cytoplasm; nucleolus; midbody; nucleus; cytosol Molecular Function:protein serine/threonine kinase activity; protein binding; metal ion binding; protein phosphatase binding; ATP binding; protein kinase activity Biological Process: mitosis; blastocyst development; regulation of attachment of spindle microtubules to kinetochore; mitotic sister chromatid segregation; protein amino acid autophosphorylation; regulation of mitotic centrosome separation; organelle organization and biogenesis; centrosome separation; spindle assembly; protein amino acid phosphorylation; negative regulation of DNA binding; chromosome segregation; meiotic cell cycle; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of mitosis; mitotic cell cycle; G2/M transition of mitotic cell cycle Disease: Retinitis Pigmentosa 67 |
NCBI Summary: | This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011] |
UniProt Code: | P51955 |
NCBI GenInfo Identifier: | 1709252 |
NCBI Gene ID: | 4751 |
NCBI Accession: | P51955.1 |
UniProt Secondary Accession: | P51955,Q53FD6, Q5I1Z9, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2 Q96QN9, |
UniProt Related Accession: | P51955 |
Molecular Weight: | 445 |
NCBI Full Name: | Serine/threonine-protein kinase Nek2 |
NCBI Synonym Full Names: | NIMA-related kinase 2 |
NCBI Official Symbol: | NEK2 |
NCBI Official Synonym Symbols: | NLK1; RP67; NEK2A; HsPK21; PPP1R111 |
NCBI Protein Information: | serine/threonine-protein kinase Nek2; nimA-like protein kinase 1; nimA-related protein kinase 2; protein phosphatase 1, regulatory subunit 111; NIMA (never in mitosis gene a)-related kinase 2 |
UniProt Protein Name: | Serine/threonine-protein kinase Nek2 |
UniProt Synonym Protein Names: | HSPK 21; Never in mitosis A-related kinase 2; NimA-related protein kinase 2; NimA-like protein kinase 1 |
Protein Family: | Serine/threonine-protein kinase |
UniProt Gene Name: | NEK2 |
UniProt Entry Name: | NEK2_HUMAN |