NEK1 Antibody (PACO58316)
- SKU:
- PACO58316
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NEK1 Antibody (PACO58316) |
Antibody SKU: | PACO58316 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Serine/threonine-protein kinase Nek1 protein (626-809AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
IHC image of PACO58316 diluted at 1:300 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. | |
Immunofluorescence staining of Hela cells with PACO58316 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
IHC image of PACO58316 diluted at 1:300 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
Background: | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. |
Synonyms: | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55), NEK1, KIAA1901 |
UniProt Protein Function: | NEK1: a protein kinase related to the NIMA (never in mitosis, gene A) serine/threonine kinase of Aspergillus nidulans. Expressed at high levels during gametogenesis and neurons of the peripheral ganglia. Implicated in the control of meiosis. Mouse mutants lead to facial malformation, male sterility and polycystic kidney disease. Two alternatively spliced human isoforms have been reported. |
UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, Other; Other group; NEK family Chromosomal Location of Human Ortholog: 4q33 Cellular Component: centrosome; cytoplasm; nucleus; pericentriolar material Molecular Function:kinase activity; protein binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity Biological Process: cilium biogenesis; protein amino acid phosphorylation Disease: Short-rib Thoracic Dysplasia 6 With Or Without Polydactyly |
NCBI Summary: | The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010] |
UniProt Code: | Q96PY6 |
NCBI GenInfo Identifier: | 22256934 |
NCBI Gene ID: | 4750 |
NCBI Accession: | Q96PY6.2 |
UniProt Secondary Accession: | Q96PY6,Q05DG5, Q14CB7, Q5H9T1, Q6PIB8, Q96SS2, Q9H6P7 Q9Y594, G5E9Z3, |
UniProt Related Accession: | Q96PY6 |
Molecular Weight: | 141,053 Da |
NCBI Full Name: | Serine/threonine-protein kinase Nek1 |
NCBI Synonym Full Names: | NIMA related kinase 1 |
NCBI Official Symbol: | NEK1 |
NCBI Official Synonym Symbols: | SRPS2; SRTD6; SRPS2A; NY-REN-55 |
NCBI Protein Information: | serine/threonine-protein kinase Nek1 |
UniProt Protein Name: | Serine/threonine-protein kinase Nek1 |
UniProt Synonym Protein Names: | Never in mitosis A-related kinase 1; NimA-related protein kinase 1; Renal carcinoma antigen NY-REN-55 |
Protein Family: | Serine/threonine-protein kinase |
UniProt Gene Name: | NEK1 |
UniProt Entry Name: | NEK1_HUMAN |