NECAB3 Antibody (PACO23379)
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주문- SKU:
- PACO23379
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NECAB3 Antibody (PACO23379) |
Antibody SKU: | PACO23379 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IF:1:100-1:500 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthesized peptide derived from internal of human NECAB3. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot analysis of extracts from COLO cells, HepG2 cells and HT-29 cells, using NECAB3 antibody. |
![]() | Immunofluorescence analysis of A549 cells, using NECAB3 antibody. |
Background: | Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation of beta-amyloid. |
Synonyms: | AB2BP; amyloid beta A4 protein-binding family A member 2-binding; APBA2BP; dJ63M2.4; dJ63M2.5 |
UniProt Protein Function: | NECAB3: Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation of beta- amyloid. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 20q11.22 Cellular Component: endoplasmic reticulum membrane; cytoplasm; Golgi cis cisterna; nucleus Molecular Function:protein binding; calcium ion binding Biological Process: regulation of amyloid precursor protein biosynthetic process; protein metabolic process; protein secretion |
NCBI Summary: | The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q96P71 |
NCBI GenInfo Identifier: | 149158725 |
NCBI Gene ID: | 63941 |
NCBI Accession: | NP_112508.3 |
UniProt Secondary Accession: | Q96P71,Q5JWF5, Q5JWF6, Q5JWF7, Q86VV1, Q9H433, Q9H8G8 Q9HBW7, Q9HCQ9, A8K780, E1P5N2, |
UniProt Related Accession: | Q96P71 |
Molecular Weight: | 44,350 Da |
NCBI Full Name: | N-terminal EF-hand calcium-binding protein 3 isoform 1 |
NCBI Synonym Full Names: | N-terminal EF-hand calcium binding protein 3 |
NCBI Official Symbol: | NECAB3 |
NCBI Official Synonym Symbols: | NIP1; XB51; STIP3; EFCBP3; SYTIP2; APBA2BP; dJ63M2.4; dJ63M2.5 |
NCBI Protein Information: | N-terminal EF-hand calcium-binding protein 3; X11L-binding protein 51; Nek2-interacting protein 1; EF-hand calcium binding protein 3; neuronal calcium-binding protein 3; synaptotagmin interacting protein 2; neuronal calcium-binding protein NECAB3; synapto |
UniProt Protein Name: | N-terminal EF-hand calcium-binding protein 3 |
UniProt Synonym Protein Names: | Amyloid beta A4 protein-binding family A member 2-binding protein; Nek2-interacting protein 1; Neuronal calcium-binding protein 3; X11L-binding protein 51 |
Protein Family: | N-terminal EF-hand calcium-binding protein |
UniProt Gene Name: | NECAB3 |
UniProt Entry Name: | NECA3_HUMAN |