NCOA5 Antibody (PACO47566)
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주문- SKU:
- PACO47566
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NCOA5 Antibody (PACO47566) |
Antibody SKU: | PACO47566 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IF:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Nuclear receptor coactivator 5 protein (112-283AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: Hela whole cell lysate, HEK293 whole cell lysate, MCF-7 whole cell lysate, Mouse heart tissue, Mouse liver tissue. All lanes: NCOA5 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 66 kDa. Observed band size: 66, 35, 25 kDa.. |
![]() | Immunofluorescent analysis of MCF-7 cells using PACO47566 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). |
Synonyms: | Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA), NCOA5, KIAA1637 |
UniProt Protein Function: | NCOA5: Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 20q13.12 Cellular Component: nucleoplasm; extracellular space; nucleus; actin cytoskeleton Molecular Function:protein binding; chromatin binding Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; negative regulation of insulin receptor signaling pathway; glucose homeostasis |
NCBI Summary: | This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9HCD5 |
NCBI GenInfo Identifier: | 28380083 |
NCBI Gene ID: | 57727 |
NCBI Accession: | Q9HCD5.2 |
UniProt Secondary Accession: | Q9HCD5,Q6HA99, Q9H1F2, Q9H2T2, Q9H4Y9, B2RTV9, E1P5R0 |
UniProt Related Accession: | Q9HCD5 |
Molecular Weight: | 579 |
NCBI Full Name: | Nuclear receptor coactivator 5 |
NCBI Synonym Full Names: | nuclear receptor coactivator 5 |
NCBI Official Symbol: | NCOA5 |
NCBI Official Synonym Symbols: | CIA; bA465L10.6 |
NCBI Protein Information: | nuclear receptor coactivator 5; NCoA-5; coactivator independent of AF-2 |
UniProt Protein Name: | Nuclear receptor coactivator 5 |
UniProt Synonym Protein Names: | Coactivator independent of AF-2; CIA |
Protein Family: | Nuclear receptor coactivator |
UniProt Gene Name: | NCOA5 |
UniProt Entry Name: | NCOA5_HUMAN |