NCF4 Antibody (PACO10754)
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주문- SKU:
- PACO10754
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NCF4 Antibody (PACO10754) |
Antibody SKU: | PACO10754 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human NCF4 |
Form: | Liquid |
Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | neutrophil cytosolic factor 4, 40kDa;NCF4;MGC3810;NCF;P40PHOX;SH3PXD4 ; |
UniProt Protein Function: | p40phox: a component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst. Upon neutrophil stimulation, this protein and other cytosolic elements are sent to the cell membrane from the cytosol to form a complex which produces phagocytic oxygen radicals. Responsible for the downregulation of NADPH-oxidase. Alternative splicing has been observed. |
UniProt Protein Details: | Protein type:Oxidoreductase Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: cytosol; endosome membrane; membrane; NADPH oxidase complex Molecular Function:phosphatidylinositol 3-phosphate binding; protein binding; protein dimerization activity; superoxide-generating NADPH oxidase activator activity Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell redox homeostasis; immune response; vascular endothelial growth factor receptor signaling pathway Disease: Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-positive, Type Iii |
NCBI Summary: | The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q15080 |
NCBI GenInfo Identifier: | 108884815 |
NCBI Gene ID: | 4689 |
NCBI Accession: | Q15080.2 |
UniProt Secondary Accession: | Q15080,O60808, Q86U56, Q9BU98, Q9NP45, A8K4F9, |
UniProt Related Accession: | Q15080 |
Molecular Weight: | 39,017 Da |
NCBI Full Name: | Neutrophil cytosol factor 4 |
NCBI Synonym Full Names: | neutrophil cytosolic factor 4 |
NCBI Official Symbol: | NCF4 |
NCBI Official Synonym Symbols: | NCF; CGD3; P40PHOX; SH3PXD4 |
NCBI Protein Information: | neutrophil cytosol factor 4 |
UniProt Protein Name: | Neutrophil cytosol factor 4 |
UniProt Synonym Protein Names: | Neutrophil NADPH oxidase factor 4; SH3 and PX domain-containing protein 4; p40-phox; p40phox |
Protein Family: | Neutrophil cytosol factor |
UniProt Gene Name: | NCF4 |
UniProt Entry Name: | NCF4_HUMAN |