NBR1 Antibody (PACO44663)
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주문- SKU:
- PACO44663
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NBR1 Antibody (PACO44663) |
Antibody SKU: | PACO44663 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Next to BRCA1 gene 1 protein (1-280AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO44663 at dilution of 1:100. |
Background: | Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. |
Synonyms: | Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B), NBR1, 1A13B KIAA0049 M17S2 |
UniProt Protein Function: | NBR1: Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. Homooligomer and heterooligomer. Interacts with TRIM55. Interacts with SQSTM1, titin/TTN, RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and ubiquitinated proteins. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 17q21.31 Cellular Component: membrane; lysosome; late endosome; M band; autophagic vacuole; cytoplasmic vesicle; cytosol Molecular Function:ubiquitin binding; protein binding; zinc ion binding; mitogen-activated protein kinase binding Biological Process: regulation of stress-activated MAPK cascade; macroautophagy; negative regulation of osteoblast differentiation; regulation of bone mineralization; protein oligomerization |
NCBI Summary: | The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014] |
UniProt Code: | Q14596 |
NCBI GenInfo Identifier: | 296439290 |
NCBI Gene ID: | 4077 |
NCBI Accession: | Q14596.3 |
UniProt Related Accession: | Q14596 |
Molecular Weight: | 103kDa; 107kDa |
NCBI Full Name: | Next to BRCA1 gene 1 protein |
NCBI Synonym Full Names: | NBR1 autophagy cargo receptor |
NCBI Official Symbol: | NBR1 |
NCBI Official Synonym Symbols: | IAI3B; M17S2; MIG19; 1A1-3B |
NCBI Protein Information: | next to BRCA1 gene 1 protein |
UniProt Protein Name: | Next to BRCA1 gene 1 protein |
UniProt Synonym Protein Names: | Cell migration-inducing gene 19 protein; Membrane component chromosome 17 surface marker 2; Neighbor of BRCA1 gene 1 protein; Protein 1A1-3B |
Protein Family: | Next to BRCA1 gene 1 protein |
UniProt Gene Name: | NBR1 |
UniProt Entry Name: | NBR1_HUMAN |
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