NBEAL2 Antibody (PACO46686)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO46686
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NBEAL2 Antibody (PACO46686) |
Antibody SKU: | PACO46686 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Neurobeachin-like protein 2 protein (1360-1574AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO46686 at dilution of 1:100. |
![]() | Immunofluorescent analysis of HepG2 cells using PACO46686 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. |
Synonyms: | Neurobeachin-like protein 2, NBEAL2, KIAA0540 |
UniProt Protein Function: | NBEAL2: Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. Defects in NBEAL2 are the cause of gray platelet syndrome (GPS). GPS is a rare platelet disorder characterized by a selective deficiency in the number and contents of platelet alpha-granules. It is associated with mild to moderate bleeding tendency and moderate thrombocytopenia. The platelets are enlarged and have a gray appearance on light microscopy of Wright-stained peripheral blood smears due to decreased granules. Belongs to the WD repeat neurobeachin family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 3p21.31 Cellular Component: endoplasmic reticulum; extrinsic to membrane Molecular Function:phospholipid binding Biological Process: platelet formation Disease: Gray Platelet Syndrome |
NCBI Summary: | The protein encoded by this gene contains a beige and Chediak-Higashi (BEACH) domain and multiple WD40 domains, and may play a role in megakaryocyte alpha-granule biogenesis. Mutations in this gene are a cause of gray platelet syndrome. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q6ZNJ1 |
NCBI GenInfo Identifier: | 149944548 |
NCBI Gene ID: | 23218 |
NCBI Accession: | NP_055990.1 |
UniProt Secondary Accession: | Q6ZNJ1,O60288, Q6P994, Q6UX91, Q8NAC9, |
UniProt Related Accession: | Q6ZNJ1 |
Molecular Weight: | 299,342 Da |
NCBI Full Name: | neurobeachin-like protein 2 |
NCBI Synonym Full Names: | neurobeachin like 2 |
NCBI Official Symbol: | NBEAL2 |
NCBI Official Synonym Symbols: | GPS; BDPLT4 |
NCBI Protein Information: | neurobeachin-like protein 2 |
UniProt Protein Name: | Neurobeachin-like protein 2 |
Protein Family: | Neurobeachin-like protein |
UniProt Gene Name: | NBEAL2 |
UniProt Entry Name: | NBEL2_HUMAN |
Antibodies |
Anti-NBEAL2 Antibody (CAB15797) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |