MYO7A Antibody (PACO20056)
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주문- SKU:
- PACO20056
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | MYO7A Antibody (PACO20056) |
Antibody SKU: | PACO20056 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human MYO7A |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20056(MYO7A Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20056(MYO7A Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. |
Synonyms: | myosin VIIA |
UniProt Protein Function: | MYO7A: an actin-based motor molecule with ATPase activity and a calcium sensitive calmodulin binding subunit. May play a role in trafficking of ribbon- synaptic vesicle complexes and renewal of outer photoreceptor disks. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity. Seven alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Motor; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q13.5 Cellular Component: stereocilium; photoreceptor inner segment; photoreceptor outer segment; lysosomal membrane; cytoplasm; apical plasma membrane; melanosome; synapse; cell cortex; cytosol; photoreceptor connecting cilium Molecular Function:actin filament binding; microfilament motor activity; calmodulin binding; protein domain specific binding; protein binding; protein homodimerization activity; spectrin binding; ADP binding; actin-dependent ATPase activity; ATP binding Biological Process: phagolysosome formation; intracellular protein transport; eye photoreceptor cell development; sensory perception of sound; pigment granule transport; visual perception; actin filament-based movement; lysosome organization and biogenesis; metabolic process; sensory perception of light stimulus; auditory receptor cell stereocilium organization and biogenesis; equilibrioception; post-embryonic organ morphogenesis Disease: Deafness, Autosomal Dominant 11; Deafness, Autosomal Recessive 2; Usher Syndrome, Type I |
NCBI Summary: | This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q13402 |
NCBI GenInfo Identifier: | 460018219 |
NCBI Gene ID: | 4647 |
NCBI Accession: | Q13402.2 |
UniProt Related Accession: | Q13402 |
Molecular Weight: | |
NCBI Full Name: | Unconventional myosin-VIIa |
NCBI Synonym Full Names: | myosin VIIA |
NCBI Official Symbol: | MYO7A |
NCBI Official Synonym Symbols: | DFNB2; MYU7A; NSRD2; USH1B; DFNA11; MYOVIIA |
NCBI Protein Information: | unconventional myosin-VIIa |
UniProt Protein Name: | Unconventional myosin-VIIa |
Protein Family: | Unconventional myosin |
UniProt Gene Name: | MYO7A |
UniProt Entry Name: | MYO7A_HUMAN |