MYL3 Antibody (PACO22757)
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주문- SKU:
- PACO22757
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MYL3 Antibody (PACO22757) |
Antibody SKU: | PACO22757 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from internal of human MYL3. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot analysis of extracts from HuvEC, K562 and Jurkat cells, using MYL3 antibody. |
Background: | Regulatory light chain of myosin. Does not bind calcium. |
Synonyms: | Myosin light chain 3; Myosin light chain 1; slow-twitch muscle B/ventricular isoform; MLC1SB; Ventricular/slow twitch myosin alkali light chain |
UniProt Protein Function: | MYL3: Regulatory light chain of myosin. Does not bind calcium. Defects in MYL3 are the cause of familial hypertrophic cardiomyopathy type 8 (CMH8). Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH8 inheritance can be autosomal dominant or recessive. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Motor Chromosomal Location of Human Ortholog: 3p21.3-p21.2 Cellular Component: I band; sarcomere; muscle myosin complex; cytosol; A band Molecular Function:actin monomer binding; structural constituent of muscle; motor activity; myosin II heavy chain binding; calcium ion binding Biological Process: skeletal muscle development; metabolic process; positive regulation of ATPase activity; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis; regulation of the force of heart contraction; muscle filament sliding; cardiac muscle contraction Disease: Cardiomyopathy, Familial Hypertrophic, 8 |
NCBI Summary: | MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008] |
UniProt Code: | P08590 |
NCBI GenInfo Identifier: | 127149 |
NCBI Gene ID: | 4634 |
NCBI Accession: | P08590.3 |
UniProt Secondary Accession: | P08590,Q9NRS8, B2R534, |
UniProt Related Accession: | P08590 |
Molecular Weight: | 195 |
NCBI Full Name: | Myosin light chain 3 |
NCBI Synonym Full Names: | myosin, light chain 3, alkali; ventricular, skeletal, slow |
NCBI Official Symbol: | MYL3 |
NCBI Official Synonym Symbols: | CMH8; VLC1; MLC1V; MLC1SB |
NCBI Protein Information: | myosin light chain 3; CMLC1; cardiac myosin light chain 1; ventricular/slow twitch myosin alkali light chain; myosin light chain 1, slow-twitch muscle B/ventricular isoform; myosin, light polypeptide 3, alkali; ventricular, skeletal, slow |
UniProt Protein Name: | Myosin light chain 3 |
UniProt Synonym Protein Names: | Cardiac myosin light chain 1; CMLC1; Myosin light chain 1, slow-twitch muscle B/ventricular isoform; MLC1SB; Ventricular/slow twitch myosin alkali light chain |
Protein Family: | Myosin |
UniProt Gene Name: | MYL3 |
UniProt Entry Name: | MYL3_HUMAN |
Antibodies | ELISA Kits |
Anti-MYL3 Antibody (CAB6662) | Human CMIC-1 / Cardiac Myosin Light Chains 1 ELISA Kit |
MYL3 Antibody (PACO01125) | Human Myosin light chain 3 (MYL3) ELISA Kit |
MYL3 Antibody (PACO10687) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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