Background: | extracellular space, mitochondrial matrix, mitochondrion, magnesium ion binding, methenyltetrahydrofolate cyclohydrolase activity, methylenetetrahydrofolate dehydrogenase (NAD+) activity, methylenetetrahydrofolate dehydrogenase (NADP+) activity, phosphate ion binding, folic acid, metabolic process, one-carbon metabolic process |
Synonyms: | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)], MTHFD2, NMDMC |
UniProt Protein Function: | MTHFD2: a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009] |
UniProt Protein Details: | Protein type:Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 3.5.4.9; Hydrolase; Oxidoreductase; EC 1.5.1.15; Mitochondrial; Cofactor and Vitamin Metabolism - one carbon pool by folate Chromosomal Location of Human Ortholog: 2p13.1 Cellular Component: cytosol; extracellular space; mitochondrial matrix; mitochondrion Molecular Function:formate-tetrahydrofolate ligase activity; magnesium ion binding; methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; methylenetetrahydrofolate dehydrogenase (NADP+) activity; phosphate binding Biological Process: folic acid metabolic process; one-carbon compound metabolic process; tetrahydrofolate metabolic process |
NCBI Summary: | This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009] |
UniProt Code: | P13995 |
NCBI GenInfo Identifier: | 115311607 |
NCBI Gene ID: | 10797 |
NCBI Accession: | P13995.2 |
UniProt Secondary Accession: | P13995,Q53G90, Q53GV5, Q53S36, Q7Z650, |
UniProt Related Accession: | P13995 |
Molecular Weight: | 26,849 Da |
NCBI Full Name: | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial |
NCBI Synonym Full Names: | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
NCBI Official Symbol: | MTHFD2 |
NCBI Official Synonym Symbols: | NMDMC |
NCBI Protein Information: | bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial |
UniProt Protein Name: | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial |
Protein Family: | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase |
UniProt Gene Name: | MTHFD2 |
UniProt Entry Name: | MTDC_HUMAN |