MTERF1 Antibody (PACO50770)
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주문- SKU:
- PACO50770
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MTERF1 Antibody (PACO50770) |
Antibody SKU: | PACO50770 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Transcription termination factor 1, mitochondrial protein (63-232AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: HL60 whole cell lysate, K562 whole cell lysate. All lanes: MTERF1 antibody at 2.6µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 46 kDa. Observed band size: 46 kDa.. |
Background: | Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand. |
Synonyms: | Transcription termination factor 1, mitochondrial (Mitochondrial transcription termination factor 1) (mTERF) (mTERF1), MTERF1, MTERF |
UniProt Protein Function: | MTERF: Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Probably requires one or more components for termination activity. Belongs to the mTERF family. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 7q21.2 Cellular Component: mitochondrion; mitochondrial matrix Molecular Function:protein binding; double-stranded DNA binding Biological Process: termination of mitochondrial transcription; mitochondrion organization and biogenesis; regulation of transcription, DNA-dependent; organelle organization and biogenesis; gene expression; transcription termination; DNA geometric change; transcription from mitochondrial promoter |
NCBI Summary: | This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q99551 |
NCBI GenInfo Identifier: | 5902010 |
NCBI Gene ID: | 7978 |
NCBI Accession: | NP_008911.1 |
UniProt Secondary Accession: | Q99551,Q32NF8, Q53H51, Q9BVR7, A4D1E3, |
UniProt Related Accession: | Q99551 |
Molecular Weight: | 45,778 Da |
NCBI Full Name: | transcription termination factor, mitochondrial |
NCBI Synonym Full Names: | mitochondrial transcription termination factor |
NCBI Official Symbol: | MTERF |
NCBI Protein Information: | transcription termination factor, mitochondrial; mitochondrial transcription termination factor 1 |
UniProt Protein Name: | Transcription termination factor, mitochondrial |
UniProt Synonym Protein Names: | Mitochondrial transcription termination factor 1 |
UniProt Gene Name: | MTERF |
UniProt Entry Name: | MTERF_HUMAN |