MTDH Antibody (PACO43753)
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주문- SKU:
- PACO43753
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IP
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | MTDH Antibody (PACO43753) |
Antibody SKU: | PACO43753 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IP |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IP:1:200-1:2000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Protein LYRIC protein (1-260AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human breast cancer using PACO43753 at dilution of 1:100. |
![]() | Immunoprecipitating MTDH in Hela whole cell lysate. Lane 1: Rabbit control IgG instead of (1µg) instead of PACO43753 in Hela whole cell lysate.For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000). Lane 2: PACO43753 (4µg) + Hela whole cell lysate (500µg). Lane 3: Hela whole cell lysate (20µg). |
![]() | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO43753 at dilution of 1:100. |
Background: | Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. |
Synonyms: | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein), MTDH, AEG1 LYRIC |
UniProt Protein Function: | Lyric: a protein of unknown function. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Nucleolus; Cell adhesion Chromosomal Location of Human Ortholog: 8q22.1 Cellular Component: nuclear body; intercellular canaliculus; endoplasmic reticulum membrane; nuclear membrane; tight junction; endoplasmic reticulum; perinuclear region of cytoplasm; apical plasma membrane; cytoplasm; nucleolus; integral to membrane; nucleus Molecular Function:NF-kappaB binding; protein binding; double-stranded RNA binding; transcription coactivator activity Biological Process: positive regulation of protein kinase B signaling cascade; positive regulation of angiogenesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; lipopolysaccharide-mediated signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of autophagy; negative regulation of apoptosis; activation of NF-kappaB transcription factor |
UniProt Code: | Q86UE4 |
NCBI GenInfo Identifier: | 28277147 |
NCBI Gene ID: | 92140 |
NCBI Accession: | AAH45642.1 |
UniProt Secondary Accession: | Q86UE4,Q05DH2, Q52QU9, Q6PK07, Q8TCX3, |
Molecular Weight: | 63,837 Da |
NCBI Full Name: | Metadherin |
NCBI Synonym Full Names: | metadherin |
NCBI Official Symbol: | MTDH |
NCBI Official Synonym Symbols: | 3D3; AEG1; AEG-1; LYRIC; LYRIC/3D3 |
NCBI Protein Information: | protein LYRIC |
UniProt Protein Name: | Protein LYRIC |
UniProt Synonym Protein Names: | 3D3/LYRIC; Astrocyte elevated gene-1 protein; AEG-1; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein |
Protein Family: | Protein LYRIC |
UniProt Gene Name: | MTDH |
UniProt Entry Name: | LYRIC_HUMAN |
Antibodies | ELISA Kits |
Anti-MTDH Antibody (CAB5887) | Human Metadherin / MTDH ELISA Kit |
Human Protein LYRIC (MTDH) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |