| UniProt Protein Function: | MRPS21: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S21P family. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 9p, 10p, 10q, 16q, and 17q. Available sequence data analyses identified splice variants that differ in the 5' UTR; both transcripts encode the same protein. [provided by RefSeq, Jul 2008]Protein type: Ribosomal; MitochondrialChromosomal Location of Human Ortholog: 1q21Cellular Component: mitochondrial inner membrane; mitochondrial small ribosomal subunitMolecular Function: structural constituent of ribosomeBiological Process: mitochondrial translation; organelle organization and biogenesis; translation |
| UniProt Protein Details: | |
| NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S21P family. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 9p, 10p, 10q, 16q, and 17q. Available sequence data analyses identified splice variants that differ in the 5' UTR; both transcripts encode the same protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P82921 |
| NCBI GenInfo Identifier: | 13959554 |
| NCBI Gene ID: | 54460 |
| NCBI Accession: | P82921.2 |
| UniProt Secondary Accession: | P82921,Q5TB11, Q9BST6 |
| UniProt Related Accession: | P82921 |
| Molecular Weight: | 10,742 Da |
| NCBI Full Name: | 28S ribosomal protein S21, mitochondrial |
| NCBI Synonym Full Names: | mitochondrial ribosomal protein S21 |
| NCBI Official Symbol: | MRPS21 |
| NCBI Official Synonym Symbols: | MDS016; RPMS21; MRP-S21 |
| NCBI Protein Information: | 28S ribosomal protein S21, mitochondrial |
| UniProt Protein Name: | 28S ribosomal protein S21, mitochondrial |
| UniProt Synonym Protein Names: | |
| Protein Family: | 28S ribosomal protein |
| UniProt Gene Name: | MRPS21 |
| UniProt Entry Name: | RT21_HUMAN |
