Mouse KLK8 Recombinant Protein (RPPB1869)

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SKU:
RPPB1869
Product type:
Recombinant Protein
Size:
10ug
Species:
Mouse
Target:
KLK8
Synonyms:
Ovasin
Synonyms:
PRSS19
Synonyms:
TADG14
Synonyms:
NRPN
Source:
Sf9 Insect cells
Uniprot:
Q61955
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Description

Product Name:Mouse KLK8 Recombinant Protein
Product Code:RPPB1869
Size:10µg
Species:Mouse
Target:KLK8
Synonyms:Ovasin, PRSS19, TADG14, NRPN, NP, Kallikrein 8(Neuropsin/Ovasin) 2 EC 3.4.21.118, Kallikrein-8, Neuropsin, EC 3.4.21 61,HNP, HK8
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:KLK8 protein 0.5mg/ml is supplied in PBS, pH-7.4, and 10%Glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:QGSKILEGRE CIPHSQPWQA ALFQGERLIC GGVLVGDRWV LTAAHCKKQK YSVRLGDHSL QSRDQPEQEI QVAQSIQHPC YNNSNPEDHS HDIMLIRLQN SANLGDKVKP VQLANLCPKV GQKCIISGWG TVTSPQENFP NTLNCAEVKI YSQNKCERAY PGKITEGMVC AGSSNGADTC QGDSGGPLVC DGMLQGITSW GSDPCGKPEK PGVYTKICRY TTWIKKTMDN RDLEHHHHHH

Kallikrein-8is a serine protease which degrades various proteins such as casein,fibrinogen, kininogen, fibronectin and collagen type IV. Kallikrein-8 takespart in the formation and maturation of orphan and small synaptic boutons inthe Schaffer-collateral pathway, regulates Schaffer-collateral long-termpotentiation in the hippocampus and is essential for memory acquisition andsynaptic plasticity. Kallikrein-8 participates in the secondary phase ofpathogenesis following spinal cord injury and also takes part in skindesquamation and keratinocyte proliferation.

KLK8 Mouse Recombinant produced in Sf9 is a single, glycosylated polypeptide chain containing 240 amino acids (29-260) and having a molecular mass of 26.5kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa). The KLK8 is fused to an 8 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:KLK8: Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer- collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. Belongs to the peptidase S1 family. Kallikrein subfamily. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; EC 3.4.21.118; Protease; Secreted; Cell development/differentiationCellular Component: extracellular space; cytoplasm; extracellular regionMolecular Function: peptidase activity; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; catalytic activityBiological Process: cell death; negative regulation of myelination; negative regulation of axon regeneration; synapse organization and biogenesis; response to wounding; regulation of synapse organization and biogenesis; keratinocyte proliferation; proteolysis; neurite morphogenesis; memory
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q61955
NCBI GenInfo Identifier:6679487
NCBI Gene ID:259277
NCBI Accession:NP_032966.1
UniProt Secondary Accession:Q61955,Q8K5D7
UniProt Related Accession:Q61955
Molecular Weight:55.7kDa
NCBI Full Name:kallikrein-8
NCBI Synonym Full Names:kallikrein related-peptidase 8
NCBI Official Symbol:Klk8  
NCBI Official Synonym Symbols:BSP1; Nrpn; Prss19  
NCBI Protein Information:kallikrein-8; NP; mK8; neuropsin; kallikrein 8; serine protease 19; Brain Serine protease 1; protease, serine, 19 (neuropsin)
UniProt Protein Name:Kallikrein-8
UniProt Synonym Protein Names:Neuropsin; NP; Serine protease 19
Protein Family:Kallikrein
UniProt Gene Name:Klk8  
UniProt Entry Name:KLK8_MOUSE
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