APC Anti-Mouse CD80 Antibody [16-10A1] (AGEL0036)

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SKU:
AGEL0036
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Hamster
Isotype:
IgG
Clone:
16-10A1
Conjugation:
APC
Applications:
FC
Frequently bought together:

Description

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APC Anti-Mouse CD80 Antibody [16-10A1]

The APC-Conjugated Mouse CD80 Monoclonal Antibody (16-10A1) is expertly designed for advanced research targeting CD80, a crucial cell surface molecule known for its role in immune activation and costimulation. This monoclonal antibody, produced in mice, is highly specific to mouse CD80 and is validated for use in flow cytometry applications. The allophycocyanin (APC) conjugation ensures bright and stable red fluorescence, facilitating precise and reliable detection.CD80, also known as B7-1, is essential for the activation of T cells and modulation of immune responses by interacting with CD28 and CTLA-4 receptors. Its pivotal role in immune response regulation makes it a valuable target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.

The APC-Conjugated Mouse CD80 Monoclonal Antibody (16-10A1) is an indispensable tool for researchers aiming to elucidate the mechanisms of immune activation and develop therapies that either harness or suppress immune function.By enabling accurate and sensitive detection of CD80, this antibody supports comprehensive studies of immune pathways, contributing to the advancement of immunotherapy and the development of innovative treatments for immune-related diseases. Understanding the activity of CD80 is crucial for creating targeted therapies that modulate immune function, making this antibody a critical asset for advancing research in immunology and cancer.

Product Title:APC Anti-Mouse CD80 Antibody [16-10A1]
SKU:AGEL0036
Size:50 Tests, 100 Tests, 200 Tests
Clone No:16-10A1
Synonyms:T-lymphocyte activation antigen CD80;Cd80;Activation B7-1 antigen;B7;
Host Species:Armenian Hamster
Reactivity:Mouse
Application:FCM
Isotype:Armenian Hamster IgG
Isotype Control:APC Armenian Hamster IgG Isotype Control[PIP]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q00609
Gene ID:12519
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD80 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is also known as B7-1, B7, and Ly-53. CD80 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD80 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD80 appears to be expressed later in the immune response than CD86. CD80 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

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