Purified Anti-Mouse CD54 Antibody [YN1/1.7.4] (AGEL0116)

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SKU:
AGEL0116
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2b
Clone:
YN1/1.7.4
Conjugation:
Unconjugated
Applications:
FC
WB
IHC
IP
Frequently bought together:

Description

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Purified Anti-Mouse CD54 Antibody [YN1/1.7.4]

The Mouse CD54 Monoclonal Antibody (YN1/1.7.4) - AGEL0116 is a valuable tool for researchers studying CD54, also known as intercellular adhesion molecule-1 (ICAM-1). This monoclonal antibody, generated against mouse samples, is highly specific and reliable for use in various experimental applications.CD54 is a cell surface glycoprotein involved in immune responses, cell adhesion, and inflammation. It plays a crucial role in the immune system by facilitating interactions between immune cells, such as leukocytes, and endothelial cells during immune surveillance and inflammatory processes. The expression of CD54 is upregulated in response to various stimuli, contributing to immune cell recruitment and activation.The YN1/1.

7.4 Mouse CD54 Monoclonal Antibody is ideal for detecting and analyzing CD54 expression in mouse samples, making it a valuable tool for research in immunology, inflammation, and infectious diseases. Its specificity and high reactivity ensure accurate and reliable results in techniques such as immunohistochemistry, flow cytometry, and immunoprecipitation.By targeting CD54 with this monoclonal antibody, researchers can gain insights into the role of this molecule in immune responses, cell signaling pathways, and inflammatory diseases. Understanding the function and regulation of CD54 is essential for developing targeted therapies and interventions for conditions where its dysregulation plays a significant role.

Product Title:Purified Anti-Mouse CD54 Antibody [YN1/1.7.4]
SKU:AGEL0116
Size:25µg, 100µg
Clone No:YN1/1.7.4
Synonyms:Intercellular adhesion molecule 1;Icam1;MALA-2;MyD10;CD54;Icam-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:Purified Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P13597
Gene ID:15894
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.

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