GenieFluor 647 Anti-Mouse CD49b Antibody [DX5] (AGEL1454)

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SKU:
AGEL1454
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
DX5
Conjugation:
AF 647
Frequently bought together:

Description

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GenieFluor 647 Anti-Mouse CD49b Antibody [DX5]

The Mouse CD49b Monoclonal Antibody (AF647 Conjugated, DX5, AGEL1454) is a cutting-edge tool designed for researchers studying CD49b, a cell surface molecule with key roles in immune response and cell adhesion. This monoclonal antibody, labeled with AF647 for fluorescent detection, specifically targets CD49b in mouse samples and is optimized for flow cytometry and immunofluorescence applications.CD49b, also known as DX5, is a marker for natural killer (NK) cells and some T cells, playing a crucial role in their cytotoxic activity and homing to specific tissues. Its expression is associated with various immune processes, including anti-tumor responses and immune surveillance.

The AF647-conjugated DX5 antibody allows precise visualization and analysis of CD49b-expressing cells, facilitating detailed studies in immunology, cancer biology, and related fields.Researchers can utilize this monoclonal antibody to investigate the function of CD49b in various immune cell populations, explore its involvement in disease progression, and assess its potential as a therapeutic target. By providing a reliable tool for detecting CD49b in mouse models, the AF647-conjugated DX5 antibody supports in-depth research into immune system dynamics and contributes to advancing our understanding of immune-mediated pathologies.

Product Title:GenieFluor 647 Anti-Mouse CD49b Antibody [DX5]
SKU:AGEL1454
Size:25µg, 100µg
Clone No:DX5
Synonyms:Integrin alpha-2;CD49 antigen-like family member B;Collagen receptor;Platelet membrane glycoprotein Ia;GPIa;VLA-2 subunit alpha;CD49b;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgM, κ
Isotype Control:Genie Fluor 647 Rat IgM, κ Isotype Control[RTK2118]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q62469
Gene ID:16398
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:DX5 antigen has been recently characterized as CD49b. It is a 150 kD integrin α chain also known as α2 integrin, VLA-2 α chain, and integrin α2 chain. CD49b non-covalently associates with CD29 (β1 integrin) to form the CD49b/CD29 complex known as VLA-2, a receptor for collagen and laminin. CD49b is expressed on platelets, the majority of NK cells, NKT cells, and a small subset of CD8+ T cells (this population can be significantly increased following viral infection). DX5 is used for the identification and isolation of NK cells, and is especially useful for identifying NK cells in mice lacking the NK1.1 antigen.

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