Purified Anti-Mouse CD45R/B220 Antibody [RA3.3A 1/6.1] (AGEL0421)

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SKU:
AGEL0421
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgM
Clone:
RA3.3A 1/6.1
Conjugation:
Unconjugated
Applications:
FC
Frequently bought together:

Description

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Purified Anti-Mouse CD45R/B220 Antibody [RA3.3A 1/6.1]

The Mouse CD45R/B220 Monoclonal Antibody (RA3-3A1/6.1) is a specialized tool for researchers studying the CD45R/B220 protein in mouse samples. This monoclonal antibody, designated AGEL0421, is specifically designed to target and detect the CD45R/B220 protein, which is a marker for B cells and subsets of T cells in mice.With its high specificity and sensitivity, the RA3-3A1/6.1 antibody provides researchers with a reliable method for identifying and analyzing CD45R/B220 expression in various cell types and tissues. Its validation for use in immunohistochemistry, flow cytometry, and other applications makes it a versatile tool for investigating immune responses, B cell biology, and lymphocyte development in mouse models.The CD45R/B220 protein is known for its crucial role in B cell maturation, activation, and signaling, making it a key target for studies in immunology, infectious diseases, and autoimmune disorders.

By using the RA3-3A1/6.1 antibody, researchers can gain valuable insights into the dynamics of B cell populations and the role of CD45R/B220 in immune function, paving the way for advancements in therapeutic strategies targeting B cell-mediated diseases.Overall, the Mouse CD45R/B220 Monoclonal Antibody (RA3-3A1/6.1) offers a reliable and specific tool for dissecting the intricacies of B cell biology and immune system regulation in mouse models, providing a valuable resource for advancing research in immunology and related fields.

Product Title:Purified Anti-Mouse CD45R/B220 Antibody [RA3.3A 1/6.1]
SKU:AGEL0421
Size:25µg, 100µg
Clone No:RA3.3A 1/6.1
Synonyms:B220;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgM, κ
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Gene ID:19264,5788
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD45R, also known as B220, is an isoform of CD45. It is a member of the protein tyrosine phosphatase (PTP) family with a molecular weight of approximately 180-240 kD. CD45R is expressed on B cells (at all developmental stages from pro-B cells through mature B cells), activated B cells, and subsets of T and NK cells. CD45R (B220) is also expressed on a subset of abnormal T cells involved in the pathogenesis of systemic autoimmunity in MRL-Faslpr and MRL-Fasgld mice. It plays a critical role in TCR and BCR signaling. The primary ligands for CD45 are galectin-1, CD2, CD3, and CD4. CD45R is commonly used as a pan-B cell marker; however, CD19 may be more appropriate for B cell specificity.

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