PE Anti-Mouse CD279/PD-1 Antibody [29F.1A12] (AGEL1633)

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SKU:
AGEL1633
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
29F.1A12
Conjugation:
PE
Frequently bought together:

Description

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PE Anti-Mouse CD279/PD-1 Antibody [29F.1A12]

The Mouse CD279 (PD-1) Monoclonal Antibody PE Conjugated (29F.1A12) is a cutting-edge tool designed for the study of the PD-1 protein, a key immune checkpoint receptor involved in the regulation of T cell activation and tolerance. This monoclonal antibody, characterized by its specificity and efficiency, is conjugated with PE for enhanced detection in flow cytometry assays.PD-1, also known as programmed cell death protein 1, is a crucial immune checkpoint receptor that plays a pivotal role in maintaining peripheral tolerance and preventing autoimmunity by suppressing T cell responses. Its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and infectious diseases.

The 29F.1A12 antibody specifically targets PD-1, allowing for precise detection and analysis of its expression in different cell populations.This PE-conjugated monoclonal antibody is essential for researchers studying immune regulation, tumor immunology, and immunotherapy. By accurately detecting PD-1 expression, researchers can gain insights into the immune evasion mechanisms employed by cancer cells and develop novel strategies to enhance antitumor immune responses. The reliable performance and high sensitivity of the 29F.1A12 antibody make it an indispensable tool for advancing research in immunology and finding innovative treatments for diseases associated with immune dysfunction.

Product Title:PE Anti-Mouse CD279/PD-1 Antibody [29F.1A12]
SKU:AGEL1633
Size:25µg, 100µg
Clone No:29F.1A12
Synonyms:PD-1; Programmed Death-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q02242
Gene ID:18566
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

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