PE Anti-Mouse CD272 Antibody [PK18.6] (AGEL0757)

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SKU:
AGEL0757
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
PK18.6
Conjugation:
PE
Frequently bought together:

Description

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PE Anti-Mouse CD272 Antibody [PK18.6]

The Mouse CD272 Monoclonal Antibody (PE Conjugated) PK18-6 (AGEL0757) from Assay Genie is a specialized tool for studying CD272, a cell surface molecule with important implications in immune regulation. This monoclonal antibody, conjugated with PE for fluorescence detection, is specifically designed for use in flow cytometry applications.CD272, also known as BTLA (B- and T-lymphocyte attenuator), is recognized for its role in modulating immune responses by suppressing T cell activation and cytokine production. The mouse CD272 Monoclonal Antibody (PE Conjugated) PK18-6 (AGEL0757) provides researchers with a precise tool to identify and analyze CD272 expression in various cell types, facilitating in-depth investigations in immunology, autoimmunity, and cancer research.

By targeting CD272, researchers can gain insights into its functions in immune regulation and its potential implications in diseases related to dysregulated immune responses. The availability of this antibody enhances the ability to explore the role of CD272 in immunological processes, paving the way for advancements in targeted therapies and potential treatment strategies for immune-related disorders.

Product Title:PE Anti-Mouse CD272 Antibody [PK18.6]
SKU:AGEL0757
Size:25µg, 100µg
Clone No:PK18.6
Synonyms:B- and T-lymphocyte attenuator;Btla;B- and T-lymphocyte-associated protein;CD272;Btla;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG1, κ
Isotype Control:PE Rat IgG1, κ Isotype Control[HRPN]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q7TSA3
Gene ID:208154
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and naïve T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported.

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